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Lpar3 Gene Detail
Summary
  • Symbol
    Lpar3
  • Name
    lysophosphatidic acid receptor 3
  • Synonyms
    Edg7, LPA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929469
    NCBI Gene: 65086
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:145926718-145991941 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 71.03 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2125 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929469
 protein coding gene Chr3:145926716-145991969 (+)
129S1/SvImJ ENSMUSG00200002511
 protein coding gene Chr3:142845222-142910505 (+)
A/J ENSMUSG00195003021
 protein coding gene Chr3:142959167-143024436 (+)
AKR/J ENSMUSG00220003411
 protein coding gene Chr3:141373074-141438354 (+)
BALB/cJ ENSMUSG00180024179
 protein coding gene Chr3:142829577-142894843 (+)
C3H/HeJ ENSMUSG00175017697
 protein coding gene Chr3:142411614-142476868 (+)
C57BL/6NJ ENSMUSG00215009242
 protein coding gene Chr3:143112925-143178155 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025721
 protein coding gene Chr3:139424540-139491031 (+)
CAST/EiJ ENSTCUG00005027328
 protein coding gene Chr3:143512625-143577726 (+)
CBA/J ENSMUSG00210004432
 protein coding gene Chr3:143088989-143154246 (+)
DBA/2J ENSMUSG00185023241
 protein coding gene Chr3:143678215-143743458 (+)
FVB/NJ ENSMUSG00205022964
 protein coding gene Chr3:141948531-142013756 (+)
JF1/MsJ ENSUMUG00000019372
 protein coding gene Chr3:142481726-142546439 (+)
LP/J ENSMUSG00230018749
 protein coding gene Chr3:145598634-145663908 (+)
NOD/ShiLtJ ENSMUSG00190004317
 protein coding gene Chr3:144049333-144114588 (+)
NZO/HlLtJ ENSMUSG00225002446
 protein coding gene Chr3:148109258-148174529 (+)
PWK/PhJ ENSLUMG00010019358
 protein coding gene Chr3:142390418-142455275 (+)
SPRET/EiJ ENSMSPG00010007934
 protein coding gene Chr3:143698110-143772617 (+)
WSB/EiJ ENSIUOG00005015128
 protein coding gene Chr3:143138750-143203960 (+)



Homology
more
  • Human Ortholog
    LPAR3, lysophosphatidic acid receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPAR3, lysophosphatidic acid receptor 3
  • Synonyms
    Edg-7, EDG7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3
  • Links
    NCBI Gene ID: 23566
    UniProt: Q9UBY5

  • Chr Location
    1p22.3; chr1:84811601-84893540 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    105
  • cDNA Data
    16
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036832 Ensembl Gene Model | MGI Sequence Detail 65224 C57BL/6J ±  kb
    transcript ENSMUST00000039164 Ensembl | MGI Sequence Detail 2464 Not Applicable  
    polypeptide ENSMUSP00000037712 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 17
      Primer pair 11
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 11
      Phenotypes 22
    • Earliest
      J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory