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Kcnip3 Gene Detail
Summary
  • Symbol
    Kcnip3
  • Name
    Kv channel interacting protein 3, calsenilin
  • Synonyms
    4933407H12Rik, Csen, DREAM, KChIP3, R74849
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929258
    NCBI Gene: 56461
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127298418-127364014 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1914 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929258
 protein coding gene Chr2:127298418-127364014 (-)
129S1/SvImJ ENSMUSG00200046712
 protein coding gene Chr2:124352316-124417345 (-)
A/J ENSMUSG00195028999
 protein coding gene Chr2:124380532-124445535 (-)
AKR/J ENSMUSG00220041217
 protein coding gene Chr2:124146098-124211138 (-)
BALB/cJ ENSMUSG00180044108
 protein coding gene Chr2:124169610-124234586 (-)
C3H/HeJ ENSMUSG00175043967
 protein coding gene Chr2:124717008-124781395 (-)
C57BL/6NJ ENSMUSG00215024731
 protein coding gene Chr2:124219733-124284617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024259
 protein coding gene Chr2:120286416-120354803 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210032885
 protein coding gene Chr2:124567434-124631830 (-)
DBA/2J ENSMUSG00185033035
 protein coding gene Chr2:124221455-124285868 (-)
FVB/NJ ENSMUSG00205026070
 protein coding gene Chr2:123375447-123440479 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230037356
 protein coding gene Chr2:125987760-126052778 (-)
NOD/ShiLtJ ENSMUSG00190015168
 protein coding gene Chr2:124345555-124410568 (-)
NZO/HlLtJ ENSMUSG00225026803
 protein coding gene Chr2:133893933-133958961 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KCNIP3, potassium voltage-gated channel interacting protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNIP3, potassium voltage-gated channel interacting protein 3
  • Synonyms
    CSEN, DREAM, KCHIP3
  • Links
    NCBI Gene ID: 30818
    UniProt: Q9Y2W7

  • Chr Location
    2q11.1; chr2:95297327-95386081 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal spatial learning, hyperactivity, hypophagia, increased sensitivity to shock, and enhanced long term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    106
  • cDNA Data
    19
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56461 NCBI Gene Model | MGI Sequence Detail 65597 C57BL/6J ±  kb
    transcript NR_110989 RefSeq | MGI Sequence Detail 2935 C57BL/6  
    polypeptide Q9QXT8 UniProt | EBI | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 5
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921323, MGI:2138928, MGI:2139540
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 11
      Gene Ontology 18
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:386947 Arcos-Encarnacion B, et al., KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer's disease. J Neuroinflammation. 2025 Jun 19;22(1):160
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory