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Thsd1 Gene Detail
Summary
  • Symbol
    Thsd1
  • Name
    thrombospondin, type I, domain 1
  • Synonyms
    4833423O18Rik, Tmtsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929096
    NCBI Gene: 56229
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22717329-22751350 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.16 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929096
 protein coding gene Chr8:22711623-22752973 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033448
 protein coding gene Chr8:20072518-20108910 (+)
A/J MGP_AJ_G0033428
 protein coding gene Chr8:19419196-19453784 (+)
AKR/J MGP_AKRJ_G0033353
 protein coding gene Chr8:20053034-20090989 (+)
BALB/cJ MGP_BALBcJ_G0033424
 protein coding gene Chr8:19542314-19577047 (+)
C3H/HeJ MGP_C3HHeJ_G0033138
 protein coding gene Chr8:20250441-20288813 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033940
 protein coding gene Chr8:20923849-20960613 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030896
 protein coding gene Chr8:16767734-16786391 (+)
CAST/EiJ MGP_CASTEiJ_G0032464
 protein coding gene Chr8:19671417-19708299 (+)
CBA/J MGP_CBAJ_G0033113
 protein coding gene Chr8:21751891-21804397 (+)
DBA/2J MGP_DBA2J_G0033268
 protein coding gene Chr8:19387601-19423906 (+)
FVB/NJ MGP_FVBNJ_G0033212
 protein coding gene Chr8:19187436-19221530 (+)
LP/J MGP_LPJ_G0033357
 protein coding gene Chr8:20068635-20104803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033255
 protein coding gene Chr8:21355203-21392385 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033959
 protein coding gene Chr8:19950450-19988603 (+)
PWK/PhJ MGP_PWKPhJ_G0032176
 protein coding gene Chr8:18978301-19012899 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032009
 protein coding gene Chr8:19339674-19380797 (+)
WSB/EiJ MGP_WSBEiJ_G0032580
 protein coding gene Chr8:20166120-20200735 (+)



Homology
more
  • Human Ortholog
    THSD1, thrombospondin type 1 domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THSD1, thrombospondin type 1 domain containing 1
  • Synonyms
    ANIB12, LMPHM13, TMTSP, UNQ3010
  • Links
    NCBI Gene ID: 55901
    neXtProt AC: NX_Q9NS62
    UniProt: Q9NS62

  • Chr Location
    13q14.3; chr13:52377167-52416373 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human THSD1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    29
  • cDNA Data
    9
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031480 Ensembl Gene Model | MGI Sequence Detail 34022 C57BL/6J ±  kb
transcript ENSMUST00000069828 Ensembl | MGI Sequence Detail 4422 Not Applicable  
polypeptide ENSMUSP00000067701 Ensembl | MGI Sequence Detail 851 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000030877 thrombospondin type-1 domain-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR038877 Thrombospondin type-1 domain-containing protein 1
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 9
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1921865, MGI:2142766
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory