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Piwil1 Gene Detail
Summary
  • Symbol
    Piwil1
  • Name
    piwi-like RNA-mediated gene silencing 1
  • Synonyms
    MIWI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928897
    NCBI Gene: 57749
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:128813135-128832538 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 67.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928897
 protein coding gene Chr5:128779588-128832538 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030120
 protein coding gene Chr5:132733095-132783319 (+)
A/J MGP_AJ_G0030087
 protein coding gene Chr5:127156687-127210879 (+)
AKR/J MGP_AKRJ_G0030021
 protein coding gene Chr5:131289367-131337498 (+)
BALB/cJ MGP_BALBcJ_G0030097
 protein coding gene Chr5:128504843-128557509 (+)
C3H/HeJ MGP_C3HHeJ_G0029814
 protein coding gene Chr5:131860151-131908435 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030550
 protein coding gene Chr5:137819007-137874447 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027775
 protein coding gene Chr5:121579807-121627094 (+)
CAST/EiJ MGP_CASTEiJ_G0029223
 protein coding gene Chr5:131109361-131167364 (+)
CBA/J MGP_CBAJ_G0029784
 protein coding gene Chr5:143201124-143255207 (+)
DBA/2J MGP_DBA2J_G0029934
 protein coding gene Chr5:127148738-127195443 (+)
FVB/NJ MGP_FVBNJ_G0029890
 protein coding gene Chr5:126201200-126258077 (+)
LP/J MGP_LPJ_G0030023
 protein coding gene Chr5:133249597-133301020 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029921
 protein coding gene Chr5:146586962-146637071 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030591
 protein coding gene Chr5:130949194-131002246 (+)
PWK/PhJ MGP_PWKPhJ_G0028937
 protein coding gene Chr5:126039874-126092764 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028774
 protein coding gene Chr5:128529308-128588205 (+)
WSB/EiJ MGP_WSBEiJ_G0029297
 protein coding gene Chr5:131615538-131663971 (+)



Homology
more
  • Human Ortholog
    PIWIL1, piwi like RNA-mediated gene silencing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIWIL1, piwi like RNA-mediated gene silencing 1
  • Synonyms
    CT80.1, HIWI, MIWI, PIWI
  • Links
    NCBI Gene ID: 9271
    neXtProt AC: NX_Q96J94
    UniProt: Q96J94

  • Chr Location
    12q24.33; chr12:130337887-130426260 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male sterility due to a block in spermatogenesis beginning at the round spermatid stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    55
  • cDNA Data
    21
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57749 NCBI Gene Model | MGI Sequence Detail 19404 C57BL/6J ±  kb
    transcript NM_021311 RefSeq | MGI Sequence Detail 3944 ZRU/MplStud  
    polypeptide Q9JMB7 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 21
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 20
      Gene Ontology 26
      Phenotypes 33
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory