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Kcnd3 Gene Detail
Summary
  • Symbol
    Kcnd3
  • Name
    potassium voltage-gated channel, Shal-related family, member 3
  • Synonyms
    Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928743
    NCBI Gene: 56543
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105359646-105581318 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.32 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5363 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928743
 protein coding gene Chr3:105359206-105581318 (+)
129S1/SvImJ ENSMUSG00200034683
 protein coding gene Chr3:101958580-102180857 (+)
A/J ENSMUSG00195025327
 protein coding gene Chr3:102379849-102601404 (+)
AKR/J ENSMUSG00220034433
 protein coding gene Chr3:100742673-100973284 (+)
BALB/cJ ENSMUSG00180016925
 protein coding gene Chr3:102325470-102546928 (+)
C3H/HeJ ENSMUSG00175026967
 protein coding gene Chr3:101860125-102081624 (+)
C57BL/6NJ ENSMUSG00215027539
 protein coding gene Chr3:102631426-102853746 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025473
 protein coding gene Chr3:99480033-99701902 (+)
CAST/EiJ ENSTCUG00005018713
 protein coding gene Chr3:102590784-102812862 (+)
CBA/J ENSMUSG00210007470
 protein coding gene Chr3:102482098-102703623 (+)
DBA/2J ENSMUSG00185020312
 protein coding gene Chr3:102959196-103187782 (+)
FVB/NJ ENSMUSG00205015313
 protein coding gene Chr3:101535201-101757510 (+)
JF1/MsJ ENSUMUG00000020778
 protein coding gene Chr3:101701714-101927650 (+)
LP/J ENSMUSG00230013599
 protein coding gene Chr3:104886481-105108765 (+)
NOD/ShiLtJ ENSMUSG00190027055
 protein coding gene Chr3:103171529-103392980 (+)
NZO/HlLtJ ENSMUSG00225016004
 protein coding gene Chr3:107356430-107582981 (+)
PWK/PhJ ENSLUMG00010025372
 protein coding gene Chr3:101768297-101993836 (+)
SPRET/EiJ ENSMSPG00010031499
 protein coding gene Chr3:101965680-102186257 (+)
WSB/EiJ ENSIUOG00005004250
 protein coding gene Chr3:102496165-102718613 (+)



Homology
more
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
  • Synonyms
    BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
  • Links
    NCBI Gene ID: 3752
    UniProt: Q9UK17

  • Chr Location
    1p13.2; chr1:111770662-111989668 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCND3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function, and display no ataxia phenotype. Homo- or heterozygosity for the dominant negative p.F227del mutation causes degeneration of several cellular compartments and trafficking defects, which affects neural electrophysiology and leads to motor coordination and balance deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    7
  • cDNA Data
    31
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040896 Ensembl Gene Model | MGI Sequence Detail 221673 C57BL/6J ±  kb
transcript ENSMUST00000118360 Ensembl | MGI Sequence Detail 2668 Not Applicable  
polypeptide ENSMUSP00000113436 Ensembl | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000786 voltage-gated potassium channel KCND3
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003975 Potassium channel, voltage dependent, Kv4
    IPR004056 Potassium channel, voltage dependent, Kv4.3
    IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
less
  • All nucleic 33
    cDNA 31
    Primer pair 2
    Antibodies 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2139949
References
more
  • Summaries
    All 79
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 15
    Phenotypes 24
  • Earliest
    J:352561 Dixon JE, et al., Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res. 1996 Oct;79(4):659-68
  • Latest
    J:379604 Fernandez A, et al., Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder. Autism Res. 2025 Nov;18(11):2192-2209
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory