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Gpr37l1 Gene Detail
Summary
  • Symbol
    Gpr37l1
  • Name
    G protein-coupled receptor 37-like 1
  • Synonyms
    CAG-18, D0Kist8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928503
    NCBI Gene: 171469
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135087988-135095419 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928503
 protein coding gene Chr1:135087972-135095419 (-)
129S1/SvImJ ENSMUSG00200007750
 protein coding gene Chr1:132701640-132709081 (-)
A/J ENSMUSG00195040960
 protein coding gene Chr1:131776196-131783667 (-)
AKR/J ENSMUSG00220044079
 protein coding gene Chr1:131654113-131661590 (-)
BALB/cJ ENSMUSG00180030667
 protein coding gene Chr1:132315825-132323279 (-)
C3H/HeJ ENSMUSG00175037207
 protein coding gene Chr1:132020379-132027846 (-)
C57BL/6NJ ENSMUSG00215045323
 protein coding gene Chr1:132017594-132025046 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014633
 protein coding gene Chr1:126763776-126771206 (-)
CAST/EiJ ENSTCUG00005034553
 protein coding gene Chr1:130938419-130945926 (-)
CBA/J ENSMUSG00210027228
 protein coding gene Chr1:131950792-131958266 (-)
DBA/2J ENSMUSG00185027858
 protein coding gene Chr1:136325293-136332771 (-)
FVB/NJ ENSMUSG00205042108
 protein coding gene Chr1:131286440-131293914 (-)
JF1/MsJ ENSUMUG00000039332
 protein coding gene Chr1:135449502-135456949 (-)
LP/J ENSMUSG00230035439
 protein coding gene Chr1:135850578-135858025 (-)
NOD/ShiLtJ ENSMUSG00190040992
 protein coding gene Chr1:131964890-131972366 (-)
NZO/HlLtJ ENSMUSG00225019588
 protein coding gene Chr1:139615826-139623785 (-)
PWK/PhJ ENSLUMG00010023100
 protein coding gene Chr1:131073736-131081180 (-)
SPRET/EiJ ENSMSPG00010011421
 protein coding gene Chr1:133875709-133883170 (-)
WSB/EiJ ENSIUOG00005042698
 protein coding gene Chr1:131708207-131715677 (-)



Homology
more
  • Human Ortholog
    GPR37L1, G protein-coupled receptor 37 like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR37L1, G protein-coupled receptor 37 like 1
  • Synonyms
    ET(B)R-LP-2, ETBR-LP-2, ETBRLP2
  • Links
    NCBI Gene ID: 9283
    UniProt: O60883

  • Chr Location
    1q32.1; chr1:202122886-202133592 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele may exhibit no abnormal phenotype, precocious cerebellum development and improved motor functions or abnormal blood pressure in female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    27
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171469 NCBI Gene Model | MGI Sequence Detail 7432 C57BL/6J ±  kb
    transcript NM_134438 RefSeq | MGI Sequence Detail 2267 C57BL/6  
    polypeptide Q99JG2 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001112 G-protein coupled receptor 37-like 1
      (term hierarchy)
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR003909 G protein-coupled receptor 37 orphan
      IPR000276 G protein-coupled receptor, rhodopsin-like
    • GlyGen
      Q99JG2 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37477, MGI:108433, MGI:2138545
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:363597 Xu J, et al., GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury. Neuron. 2025 Feb 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory