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Tdo2 Gene Detail
Summary
  • Symbol
    Tdo2
  • Name
    tryptophan 2,3-dioxygenase
  • Synonyms
    chky, TDO, TO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928486
    NCBI Gene: 56720
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:81865719-81883035 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928486
 protein coding gene Chr3:81864397-81883509 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027323
 protein coding gene Chr3:81751816-81771560 (-)
A/J MGP_AJ_G0027285
 protein coding gene Chr3:79043931-79064075 (-)
AKR/J MGP_AKRJ_G0027253
 protein coding gene Chr3:80913036-80932859 (-)
BALB/cJ MGP_BALBcJ_G0027296
 protein coding gene Chr3:79145322-79164908 (-)
C3H/HeJ MGP_C3HHeJ_G0027040
 protein coding gene Chr3:81198618-81222513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027742
 protein coding gene Chr3:84860413-84877028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025095
 protein coding gene Chr3:74810712-74828815 (-)
CAST/EiJ MGP_CASTEiJ_G0026487
 protein coding gene Chr3:81370838-81392777 (-)
CBA/J MGP_CBAJ_G0027015
 protein coding gene Chr3:87694629-87718612 (-)
DBA/2J MGP_DBA2J_G0027151
 protein coding gene Chr3:78603910-78625633 (-)
FVB/NJ MGP_FVBNJ_G0027119
 protein coding gene Chr3:76892884-76909685 (-)
LP/J MGP_LPJ_G0027259
 protein coding gene Chr3:82750642-82770564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027138
 protein coding gene Chr3:94077153-94098894 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027800
 protein coding gene Chr3:80712895-80735565 (-)
PWK/PhJ MGP_PWKPhJ_G0026221
 protein coding gene Chr3:78334924-78354461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026037
 protein coding gene Chr3:79928669-79949140 (-)
WSB/EiJ MGP_WSBEiJ_G0026565
 protein coding gene Chr3:81058259-81078768 (-)



Homology
more
  • Human Ortholog
    TDO2, tryptophan 2,3-dioxygenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TDO2, tryptophan 2,3-dioxygenase
  • Synonyms
    HYPTRP, TDO, TO, TPH2, TRPO
  • Links
    NCBI Gene ID: 6999
    neXtProt AC: NX_P48775
    UniProt: P48775

  • Chr Location
    4q32.1; chr4:155854738-155920406 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TDO2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased plasma and brain levels of tryptophan, increased serotonin levels in the brain, decreased anxiety-related behavior, increased neuronal precursor proliferation and accelerated neurogenesis in the granule cell layer of the olfactory bulb.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    111
  • cDNA Data
    99
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56720 NCBI Gene Model | MGI Sequence Detail 17317 C57BL/6J ±  kb
    transcript NM_019911 RefSeq | MGI Sequence Detail 1646 FVB/N  
    polypeptide P48776 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 100
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139552, MGI:3617202
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:54660 Kamiya A, et al., Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
    • Latest
      J:339671 Sin R, et al., Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. Brain Behav Immun. 2023 Aug 23;114:173-186
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory