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Acp3 Gene Detail
Summary
  • Symbol
    Acp3
  • Name
    acid phosphatase 3
  • Synonyms
    A030005E02Rik, Acpp, PAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928480
    NCBI Gene: 56318
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:104165439-104214921 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928480
 protein coding gene Chr9:104165439-104214947 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035208
 protein coding gene Chr9:105947825-105999915 (-)
A/J MGP_AJ_G0035188
 protein coding gene Chr9:102139771-102189102 (-)
AKR/J MGP_AKRJ_G0035120
 protein coding gene Chr9:104677852-104727055 (-)
BALB/cJ MGP_BALBcJ_G0035181
 protein coding gene Chr9:101852080-101901325 (-)
C3H/HeJ MGP_C3HHeJ_G0034891
 protein coding gene Chr9:105053544-105103361 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035701
 protein coding gene Chr9:108874324-108923513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032599
 protein coding gene Chr9:99702597-99753458 (-)
CAST/EiJ MGP_CASTEiJ_G0034203
 protein coding gene Chr9:104933944-104985846 (-)
CBA/J MGP_CBAJ_G0034860
 protein coding gene Chr9:112671343-112730093 (-)
DBA/2J MGP_DBA2J_G0035021
 protein coding gene Chr9:101620841-101671266 (-)
FVB/NJ MGP_FVBNJ_G0034969
 protein coding gene Chr9:100423749-100476374 (-)
LP/J MGP_LPJ_G0035097
 protein coding gene Chr9:106155083-106205139 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035008
 protein coding gene Chr9:114423703-114475320 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035723
 protein coding gene Chr9:104907251-104958123 (-)
PWK/PhJ MGP_PWKPhJ_G0033910
 protein coding gene Chr9:101906883-101956558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033745
 protein coding gene Chr9:104995872-105049768 (-)
WSB/EiJ MGP_WSBEiJ_G0034323
 protein coding gene Chr9:104796958-104849711 (-)



Homology
more
  • Human Ortholog
    ACP3, acid phosphatase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACP3, acid phosphatase 3
  • Synonyms
    5'-NT, ACP-3, ACPP, TM-PAP
  • Links
    NCBI Gene ID: 55
    neXtProt AC: NX_P15309
    UniProt: P15309

  • Chr Location
    3q22.1; chr3:132317369-132368302 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acp3 mouse models; 1 with human ACP3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased thermal nociceptive threshold and mechanical allodynia in chronic inflammatory and nerve injury pain models.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    901
  • Tissues
    99
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56318 NCBI Gene Model | MGI Sequence Detail 49483 C57BL/6J ±  kb
    transcript NM_207668 RefSeq | MGI Sequence Detail 4488 C57BL/6  
    polypeptide Q8CE08 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925165, MGI:2143020
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:72306 Roiko K, et al., Primary structure of rat secretory acid phosphatase and comparison to other acid phosphatases. Gene. 1990 May 14;89(2):223-9
    • Latest
      J:279439 Rahimi-Balaei M, et al., Loss of prostatic acid phosphatase and alpha-synuclein cause motor circuit degeneration without altering cerebellar patterning. PLoS One. 2019;14(9):e0222234
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory