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Rgs18 Gene Detail
Summary
  • Symbol
    Rgs18
  • Name
    regulator of G-protein signaling 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927498
    NCBI Gene: 64214
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:144628430-144651165 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927498
 protein coding gene Chr1:144628421-144651173 (-)
129S1/SvImJ ENSMUSG00200007209
 protein coding gene Chr1:142101173-142123980 (-)
A/J ENSMUSG00195015747
 protein coding gene Chr1:141423025-141445792 (-)
AKR/J ENSMUSG00220002725
 protein coding gene Chr1:141172237-141194981 (-)
BALB/cJ ENSMUSG00180011257
 protein coding gene Chr1:141633015-141655769 (-)
C3H/HeJ ENSMUSG00175006455
 protein coding gene Chr1:141640483-141663246 (-)
C57BL/6NJ ENSMUSG00215010034
 protein coding gene Chr1:141562401-141585154 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014682
 protein coding gene Chr1:135959586-135984407 (-)
CAST/EiJ ENSTCUG00005013091
 protein coding gene Chr1:140353732-140376474 (-)
CBA/J ENSMUSG00210013854
 protein coding gene Chr1:141561179-141583946 (-)
DBA/2J ENSMUSG00185006960
 protein coding gene Chr1:145881621-145904374 (-)
FVB/NJ ENSMUSG00205002207
 protein coding gene Chr1:140776764-140799525 (-)
JF1/MsJ ENSUMUG00000011786
 protein coding gene Chr1:145195319-145218039 (-)
LP/J ENSMUSG00230000094
 protein coding gene Chr1:145395061-145417810 (-)
NOD/ShiLtJ ENSMUSG00190002199
 protein coding gene Chr1:141396536-141419322 (-)
NZO/HlLtJ ENSMUSG00225000063
 protein coding gene Chr1:149159781-149182585 (-)
PWK/PhJ ENSLUMG00010001799
 protein coding gene Chr1:140485583-140508328 (-)
SPRET/EiJ ENSMSPG00010012216
 protein coding gene Chr1:143446929-143469620 (-)
WSB/EiJ ENSIUOG00005027060
 protein coding gene Chr1:140982889-141005712 (-)



Homology
more
  • Human Ortholog
    RGS18, regulator of G protein signaling 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS18, regulator of G protein signaling 18
  • Synonyms
    RGS13
  • Links
    NCBI Gene ID: 64407
    UniProt: Q9NS28

  • Chr Location
    1q31.2; chr1:192158462-192185815 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show reduced thermal nociception threshold, increased startle reflex, thrombocytopenia, defective megakaryopoiesis, and increased platelet aggregation. Homozygotes for a different null allele show decreased bleeding time, increased platelet aggregation, and thrombosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    15
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 64214 NCBI Gene Model | MGI Sequence Detail 22736 C57BL/6J ±  kb
transcript NM_022881 RefSeq | MGI Sequence Detail 2014 C57BL/6  
polypeptide Q99PG4 UniProt | EBI | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65933 Park IK, et al., Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001 Jan 12;276(2):915-23
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory