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Chst11 Gene Detail
Summary
  • Symbol
    Chst11
  • Name
    carbohydrate sulfotransferase 11
  • Synonyms
    1110020P09Rik, C4ST, C4ST1, C4ST-1, chondroitin 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927166
    NCBI Gene: 58250
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:82821332-83031734 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 40.66 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1044 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927166
 protein coding gene Chr10:82820274-83031738 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017583
 protein coding gene Chr10:83756848-83977760 (+)
A/J MGP_AJ_G0017563
 protein coding gene Chr10:80924304-81136137 (+)
AKR/J MGP_AKRJ_G0017522
 protein coding gene Chr10:83178193-83392607 (+)
BALB/cJ MGP_BALBcJ_G0017526
 protein coding gene Chr10:81195505-81411192 (+)
C3H/HeJ MGP_C3HHeJ_G0017348
 protein coding gene Chr10:83251691-83474966 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017983
 protein coding gene Chr10:86675681-86907076 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015667
 protein coding gene Chr10:76656903-76870411 (+)
CAST/EiJ MGP_CASTEiJ_G0016915
 protein coding gene Chr10:83165996-83406284 (+)
CBA/J MGP_CBAJ_G0017318
 protein coding gene Chr10:90248999-90487157 (+)
DBA/2J MGP_DBA2J_G0017424
 protein coding gene Chr10:80095113-80305994 (+)
FVB/NJ MGP_FVBNJ_G0017418
 protein coding gene Chr10:79327535-79545230 (+)
LP/J MGP_LPJ_G0017496
 protein coding gene Chr10:84402229-84618076 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017446
 protein coding gene Chr10:91913132-92130239 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018020
 protein coding gene Chr10:83115654-83333165 (+)
PWK/PhJ MGP_PWKPhJ_G0016696
 protein coding gene Chr10:79975502-80190063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016486
 protein coding gene Chr10:81801773-82013579 (+)
WSB/EiJ MGP_WSBEiJ_G0016974
 protein coding gene Chr10:83141807-83363307 (+)



Homology
more
  • Human Ortholog
    CHST11, carbohydrate sulfotransferase 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHST11, carbohydrate sulfotransferase 11
  • Synonyms
    C4ST, C4ST1, C4ST-1, HSA269537, OCBMD
  • Links
    NCBI Gene ID: 50515
    neXtProt AC: NX_Q9NPF2
    UniProt: Q9NPF2

  • Chr Location
    12q23.3; chr12:104455295-104762014 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, dwarfism, and abnormal skeletal structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    122
  • cDNA Data
    7
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034612 Ensembl Gene Model | MGI Sequence Detail 210403 C57BL/6J ±  kb
    transcript ENSMUST00000040110 Ensembl | MGI Sequence Detail 5527 Not Applicable  
    polypeptide ENSMUSP00000045349 Ensembl | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915897
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:333815 Tao C, et al., Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate. Development. 2022 Jun 15;149(12):dev200569
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory