Dusp10 MGI Mouse Gene Detail - MGI:1927070 - dual specificity phosphatase 10

Symbol

Dusp10
Name

dual specificity phosphatase 10
Synonyms

2610306G15Rik, MKP-5, MKP5

Feature Type

protein coding gene
IDs

MGI:1927070
NCBI Gene: 63953
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:183766575-183807833 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 88.20 cM, cytoband H5
Mapping Data

3 experiments

SNPs within 2kb

1037 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927070	protein coding gene	Chr1:183745499-183807833 (+)
129S1/SvImJ	ENSMUSG00200021760	protein coding gene	Chr1:181521466-181584498 (+)
A/J	ENSMUSG00195040433	protein coding gene	Chr1:181106755-181169801 (+)
AKR/J	ENSMUSG00220020511	protein coding gene	Chr1:180325858-180388948 (+)
BALB/cJ	ENSMUSG00180035367	protein coding gene	Chr1:181172914-181235956 (+)
C3H/HeJ	ENSMUSG00175033662	protein coding gene	Chr1:181348446-181411481 (+)
C57BL/6NJ	ENSMUSG00215016663	protein coding gene	Chr1:180560540-180622877 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015013	protein coding gene	Chr1:173898341-173959728 (+)
CAST/EiJ	ENSTCUG00005041615	protein coding gene	Chr1:179114176-179177243 (+)
CBA/J	ENSMUSG00210018938	protein coding gene	Chr1:180996655-181059024 (+)
DBA/2J	ENSMUSG00185032830	protein coding gene	Chr1:185616139-185678503 (+)
FVB/NJ	ENSMUSG00205031674	protein coding gene	Chr1:180049215-180112294 (+)
JF1/MsJ	ENSUMUG00000005304	protein coding gene	Chr1:184617131-184679565 (+)
LP/J	ENSMUSG00230023088	protein coding gene	Chr1:185180584-185243607 (+)
NOD/ShiLtJ	ENSMUSG00190026668	protein coding gene	Chr1:181022964-181085984 (+)
NZO/HlLtJ	ENSMUSG00225010951	protein coding gene	Chr1:188919327-188981659 (+)
PWK/PhJ	ENSLUMG00010015626	protein coding gene	Chr1:179871564-179933922 (+)
SPRET/EiJ	ENSMSPG00010031665	protein coding gene	Chr1:183375171-183437704 (+)
WSB/EiJ	ENSIUOG00005011266	protein coding gene	Chr1:180215885-180278856 (+)

Human Ortholog

DUSP10, dual specificity phosphatase 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP10, dual specificity phosphatase 10
Synonyms

MKP-5, MKP5
Links

HGNC:3065

NCBI Gene ID: 11221

UniProt: Q9Y6W6
Chr Location

1q41; chr1:221700669-221742089 (-) GRCh38

MGI Vertebrate Homology

Dusp10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP10
Gene Tree

Dusp10

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

6
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

Mice homozygous for a knock-out allele display alterations in both innate and adaptive immune responses.

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All GO Annotations

64
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

179
cDNA Data

35
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

8
UniProt

2
CCDS

CCDS15591.1

Ensembl

ENSMUSG00000039384 (Evidence)
NCBI Gene

63953

			Length	Strain/Species	Flank
genomic	63953	NCBI Gene Model \| MGI Sequence Detail	41259	C57BL/6J	± kb
transcript	NM_022019	RefSeq \| MGI Sequence Detail	2792	C57BL/6
polypeptide	Q9ESS0	UniProt \| EBI \| MGI Sequence Detail	483	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006737 dual specificity protein phosphatase 10

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain
GlyGen

Q9ESS0 1 site

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All nucleic 38

cDNA 36

Primer pair 2

Antibodies 1

Microarray probesets 4

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MGI:1914422, MGI:2138165

Summaries

All 71

Developmental Gene Expression 13

Gene Ontology 16

Phenotypes 19
Earliest

J:65173 Masuda K, et al., Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10. Cytogenet Cell Genet. 2000;90(1-2):71-4
Latest

J:390693 Perales JA, et al., MAP Kinase Phosphatase-5 Deficiency Improves Endurance Exercise Capacity. Cells. 2025 Mar 11;14(6)

TSS for Dusp10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10576	Chr1:183765869-183765882 (+)	-699 bp
Tssr10577	Chr1:183766572-183766583 (+)	3 bp
Tssr10578	Chr1:183766623-183766634 (+)	54 bp
Tssr10579	Chr1:183766650-183766670 (+)	85 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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