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Tdh Gene Detail
Summary
  • Symbol
    Tdh
  • Name
    L-threonine dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926231
    NCBI Gene: 58865
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63729796-63746541 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.31 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926231
 protein coding gene Chr14:63729796-63746541 (-)
129S1/SvImJ ENSMUSG00200025890
 protein coding gene Chr14:52338393-52355128 (-)
A/J ENSMUSG00195014429
 protein coding gene Chr14:52528523-52545211 (-)
AKR/J ENSMUSG00220027627
 protein coding gene Chr14:51869016-51885705 (-)
BALB/cJ ENSMUSG00180030554
 protein coding gene Chr14:52144624-52161313 (-)
C3H/HeJ ENSMUSG00175030518
 protein coding gene Chr14:53874716-53891451 (-)
C57BL/6NJ ENSMUSG00215013133
 protein coding gene Chr14:52062353-52079102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019406
 protein coding gene Chr14:54643227-54660220 (-)
CAST/EiJ ENSTCUG00005038713
 protein coding gene Chr14:53797435-53814127 (-)
CBA/J ENSMUSG00210036531
 protein coding gene Chr14:52516015-52532704 (-)
DBA/2J ENSMUSG00185029124
 protein coding gene Chr14:57672516-57689251 (-)
FVB/NJ ENSMUSG00205032528
 protein coding gene Chr14:52031405-52048095 (-)
JF1/MsJ ENSUMUG00000043206
 protein coding gene Chr14:68861071-68877724 (-)
LP/J ENSMUSG00230034792
 protein coding gene Chr14:69702056-69718791 (-)
NOD/ShiLtJ ENSMUSG00190031124
 protein coding gene Chr14:52310783-52327472 (-)
NZO/HlLtJ ENSMUSG00225045469
 protein coding gene Chr14:60043790-60060477 (-)
PWK/PhJ ENSLUMG00010032693
 protein coding gene Chr14:51744855-51761542 (-)
SPRET/EiJ ENSMSPG00010031260
 protein coding gene Chr14:55225304-55242714 (-)
WSB/EiJ ENSIUOG00005039390
 protein coding gene Chr14:51748275-51765016 (-)



Homology
more
  • Human Ortholog
    TDH, L-threonine dehydrogenase (pseudogene)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TDH, L-threonine dehydrogenase (pseudogene)
  • Synonyms
    SDR14E1P, TDHP
  • Links
    NCBI Gene ID: 157739
    UniProt: Q8IZJ6

  • Chr Location
    8p23.1; chr8:11339637-11368452 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    103
  • cDNA Data
    32
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 58865 NCBI Gene Model | MGI Sequence Detail 16746 C57BL/6J ±  kb
transcript NM_021480 RefSeq | MGI Sequence Detail 2502 C57BL/6  
polypeptide Q8K3F7 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 32
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:310907 Nacarino-Palma A, et al., The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development. Stem Cell Reports. 2021 Sep 14;16(9):2351-2363
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory