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Igsf3 Gene Detail
Summary
  • Symbol
    Igsf3
  • Name
    immunoglobulin superfamily, member 3
  • Synonyms
    1700016K10Rik, 2810035F16Rik, 4833439O17Rik, mKIAA0466
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926158
    NCBI Gene: 78908
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:101284399-101370375 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 44.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2391 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926158
 protein coding gene Chr3:101284306-101370375 (+)
129S1/SvImJ ENSMUSG00200044191
 protein coding gene Chr3:97889804-97987129 (+)
A/J ENSMUSG00195045496
 protein coding gene Chr3:98295474-98392862 (+)
AKR/J ENSMUSG00220040530
 protein coding gene Chr3:96654919-96753027 (+)
BALB/cJ ENSMUSG00180033642
 protein coding gene Chr3:98235073-98332490 (+)
C3H/HeJ ENSMUSG00175022092
 protein coding gene Chr3:97781247-97878610 (+)
C57BL/6NJ ENSMUSG00215014367
 protein coding gene Chr3:98547258-98644595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025431
 protein coding gene Chr3:95499602-95586844 (+)
CAST/EiJ ENSTCUG00005019088
 protein coding gene Chr3:98505024-98602415 (+)
CBA/J ENSMUSG00210051174
 protein coding gene Chr3:98403420-98500775 (+)
DBA/2J ENSMUSG00185041467
 protein coding gene Chr3:98890452-98988603 (+)
FVB/NJ ENSMUSG00205017889
 protein coding gene Chr3:97466744-97564081 (+)
JF1/MsJ ENSUMUG00000021660
 protein coding gene Chr3:97596054-97689589 (+)
LP/J ENSMUSG00230043773
 protein coding gene Chr3:100818369-100915693 (+)
NOD/ShiLtJ ENSMUSG00190042555
 protein coding gene Chr3:99077015-99174300 (+)
NZO/HlLtJ ENSMUSG00225017355
 protein coding gene Chr3:103269311-103366626 (+)
PWK/PhJ ENSLUMG00010027748
 protein coding gene Chr3:97688160-97774605 (+)
SPRET/EiJ ENSMSPG00010038713
 protein coding gene Chr3:97938653-98023877 (+)
WSB/EiJ ENSIUOG00005030981
 protein coding gene Chr3:98421123-98518052 (+)



Homology
more
  • Human Ortholog
    IGSF3, immunoglobulin superfamily member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGSF3, immunoglobulin superfamily member 3
  • Synonyms
    EWI-3, LCDD, V8
  • Links
    NCBI Gene ID: 3321
    UniProt: O75054

  • Chr Location
    1p13.1; chr1:116574398-116667820 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGSF3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show reduced migration of vagal neural crest cells and impaired development of the enteric nervous system, with defects in formation of the muscularis externa and disorganized innervation of the enteric villi in the small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    3
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042035 Ensembl Gene Model | MGI Sequence Detail 85977 C57BL/6J ±  kb
    transcript ENSMUST00000195164 Ensembl | MGI Sequence Detail 3876 Not Applicable  
    polypeptide ENSMUSP00000141823 Ensembl | MGI Sequence Detail 1214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031371 immunoglobulin superfamily member 3
      (term hierarchy)
    • InterPro Domains
      IPR060656 IgSF3/IGSF8/FPRP, immunoglobulin-like domain
      IPR003599 Immunoglobulin domain subtype
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR051102 Immunoglobulin superfamily V-set and transmembrane domain-containing protein
      IPR013106 Immunoglobulin V-set domain
    • GlyGen
      Q6ZQA6 6 sites, 6 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919956, MGI:1922800
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:361913 Cocito C, et al., Immunoglobulin superfamily 3 (Igsf3) function is dispensable for brain development. Sci Rep. 2025 Feb 23;15(1):6526
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory