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Ascc3 Gene Detail
Summary
  • Symbol
    Ascc3
  • Name
    activating signal cointegrator 1 complex subunit 3
  • Synonyms
    ASC1p200, B630009I04Rik, Helic1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925237
    NCBI Gene: 77987
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:50468756-50727300 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 24.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925237
 protein coding gene Chr10:50468756-50727581 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017212
 protein coding gene Chr10:49661810-49944870 (+)
A/J MGP_AJ_G0017188
 protein coding gene Chr10:48189247-48453333 (+)
AKR/J MGP_AKRJ_G0017147
 protein coding gene Chr10:49114155-49372162 (+)
BALB/cJ MGP_BALBcJ_G0017149
 protein coding gene Chr10:48341302-48603216 (+)
C3H/HeJ MGP_C3HHeJ_G0016973
 protein coding gene Chr10:49366712-49634863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017607
 protein coding gene Chr10:51228965-51509190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015302
 protein coding gene Chr10:45642571-45911340 (+)
CAST/EiJ MGP_CASTEiJ_G0016547
 protein coding gene Chr10:49519543-49794713 (+)
CBA/J MGP_CBAJ_G0016944
 protein coding gene Chr10:53500130-53792341 (+)
DBA/2J MGP_DBA2J_G0017049
 protein coding gene Chr10:47652525-47911086 (+)
FVB/NJ MGP_FVBNJ_G0017043
 protein coding gene Chr10:47020775-47269330 (+)
LP/J MGP_LPJ_G0017124
 protein coding gene Chr10:49692610-49980602 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017072
 protein coding gene Chr10:55279913-55591970 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017643
 protein coding gene Chr10:49075511-49341460 (+)
PWK/PhJ MGP_PWKPhJ_G0016326
 protein coding gene Chr10:47492392-47760536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016111
 protein coding gene Chr10:48667555-48946479 (+)
WSB/EiJ MGP_WSBEiJ_G0016610
 protein coding gene Chr10:49286673-49556219 (+)



Homology
more
  • Human Ortholog
    ASCC3, activating signal cointegrator 1 complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASCC3, activating signal cointegrator 1 complex subunit 3
  • Synonyms
    ASC1p200, HELIC1, MRT81, RNAH
  • Links
    NCBI Gene ID: 10973
    neXtProt AC: NX_Q8N3C0
    UniProt: Q8N3C0

  • Chr Location
    6q16.3; chr6:100508194-100881372 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    59
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77987 NCBI Gene Model | MGI Sequence Detail 258545 C57BL/6J ±  kb
    transcript NM_198007 RefSeq | MGI Sequence Detail 7477 C57BL/6  
    polypeptide E9PZJ8 UniProt | EBI | MGI Sequence Detail 2198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 59
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3039633
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:246912 Ye A, et al., PEG3 control on the mammalian MSL complex. PLoS One. 2017;12(6):e0178363
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory