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Tmem50b Gene Detail
Summary
  • Symbol
    Tmem50b
  • Name
    transmembrane protein 50B
  • Synonyms
    B230114J08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925225
    NCBI Gene: 77975
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91371390-91394573 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 53.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925225
 protein coding gene Chr16:91371390-91394688 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023043
 protein coding gene Chr16:92595628-92620675 (-)
A/J MGP_AJ_G0023011
 protein coding gene Chr16:88268115-88291142 (-)
AKR/J MGP_AKRJ_G0022981
 protein coding gene Chr16:90931129-90956327 (-)
BALB/cJ MGP_BALBcJ_G0023013
 protein coding gene Chr16:88794840-88818289 (-)
C3H/HeJ MGP_C3HHeJ_G0022774
 protein coding gene Chr16:91510697-91533654 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023460
 protein coding gene Chr16:95587792-95616216 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020962
 protein coding gene Chr16:85960866-85988434 (-)
CAST/EiJ MGP_CASTEiJ_G0022293
 protein coding gene Chr16:92070417-92094526 (-)
CBA/J MGP_CBAJ_G0022743
 protein coding gene Chr16:99667268-99700833 (-)
DBA/2J MGP_DBA2J_G0022877
 protein coding gene Chr16:88169611-88193004 (-)
FVB/NJ MGP_FVBNJ_G0022851
 protein coding gene Chr16:87296959-87320137 (-)
LP/J MGP_LPJ_G0022947
 protein coding gene Chr16:92301178-92325875 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022872
 protein coding gene Chr16:104222117-104246230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023478
 protein coding gene Chr16:91451832-91478933 (-)
PWK/PhJ MGP_PWKPhJ_G0022038
 protein coding gene Chr16:88346189-88371539 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021868
 protein coding gene Chr16:91013996-91038861 (-)
WSB/EiJ MGP_WSBEiJ_G0022345
 protein coding gene Chr16:91695170-91719996 (-)



Homology
more
  • Human Ortholog
    TMEM50B, transmembrane protein 50B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM50B, transmembrane protein 50B
  • Synonyms
    C21orf4, HCVP7TP3
  • Links
    NCBI Gene ID: 757
    neXtProt AC: NX_P56557
    UniProt: P56557

  • Chr Location
    21q22.11; chr21:33432485-33479974 (-)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1321
  • Tissues
    241
  • cDNA Data
    102
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77975 NCBI Gene Model | MGI Sequence Detail 23184 C57BL/6J ±  kb
    transcript NM_001419296 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q9D1X9 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 102
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146537, MGI:2146555
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 8
      Diseases 4
      Gene Ontology 4
      Phenotypes 78
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory