About   Help   FAQ
Dnhd1 Gene Detail
Summary
  • Symbol
    Dnhd1
  • Name
    dynein heavy chain domain 1
  • Synonyms
    8030491N06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924755
    NCBI Gene: 77505
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105300034-105371006 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.93 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924755
 protein coding gene Chr7:105299983-105371007 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032760
 protein coding gene Chr7:108903663-108989677 (+)
A/J MGP_AJ_G0032740
 protein coding gene Chr7:106050452-106136878 (+)
AKR/J MGP_AKRJ_G0032673
 protein coding gene Chr7:108824605-108907093 (+)
BALB/cJ MGP_BALBcJ_G0032746
 protein coding gene Chr7:105766980-105850539 (+)
C3H/HeJ MGP_C3HHeJ_G0032455
 protein coding gene Chr7:108932260-109013491 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033251
 protein coding gene Chr7:113263908-113349311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030235
 protein coding gene Chr7:108029211-108108811 (+)
CAST/EiJ MGP_CASTEiJ_G0031785
 protein coding gene Chr7:100758938-100840361 (+)
CBA/J MGP_CBAJ_G0032429
 protein coding gene Chr7:117027381-117123746 (+)
DBA/2J MGP_DBA2J_G0032582
 protein coding gene Chr7:104320068-104401775 (+)
FVB/NJ MGP_FVBNJ_G0032535
 protein coding gene Chr7:104129076-104209138 (+)
LP/J MGP_LPJ_G0032673
 protein coding gene Chr7:110307223-110394271 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032567
 protein coding gene Chr7:118613779-118701627 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033272
 protein coding gene Chr7:107891826-107978552 (+)
PWK/PhJ MGP_PWKPhJ_G0031498
 protein coding gene Chr7:97260310-97342498 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031347
 protein coding gene Chr7:95002305-95088935 (+)
WSB/EiJ MGP_WSBEiJ_G0031902
 protein coding gene Chr7:108534351-108615649 (+)



Homology
more
  • Human Ortholog
    DNHD1, dynein heavy chain domain 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNHD1, dynein heavy chain domain 1
  • Synonyms
    C11orf47, CCDC35, DHCD1, DNHD1L, SPGF65
  • Links
    NCBI Gene ID: 144132
    neXtProt AC: NX_Q96M86
    UniProt: Q96M86

  • Chr Location
    11p15.4; chr11:6497260-6593758 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DNHD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a null allele exhibit male infertility, reduced sperm numbers and sperm motility, and abnormalities of sperm flagella.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    7
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      34
    • RefSeq
      2
    • UniProt
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030882 Ensembl Gene Model | MGI Sequence Detail 70973 C57BL/6J ±  kb
    transcript ENSMUST00000145988 Ensembl | MGI Sequence Detail 14536 Not Applicable  
    polypeptide ENSMUSP00000121261 Ensembl | MGI Sequence Detail 4750 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000032005 dynein heavy chain domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR026983 Dynein heavy chain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR024317 Dynein heavy chain, AAA module D4
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 12

      Microarray probesets 1
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:321189 Tan C, et al., Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice. Am J Hum Genet. 2022 Jan 6;109(1):157-171
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory