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Kidins220 Gene Detail
Summary
  • Symbol
    Kidins220
  • Name
    kinase D-interacting substrate 220
  • Synonyms
    3110039L19Rik, C330002I19Rik, mKIAA1250
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924730
    NCBI Gene: 77480
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:25024924-25113151 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.54 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924730
 protein coding gene Chr12:25024909-25113151 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019634
 protein coding gene Chr12:22669521-22757353 (+)
A/J MGP_AJ_G0019601
 protein coding gene Chr12:22044376-22135706 (+)
AKR/J MGP_AKRJ_G0019572
 protein coding gene Chr12:22782384-22873834 (+)
BALB/cJ MGP_BALBcJ_G0019578
 protein coding gene Chr12:22314355-22402664 (+)
C3H/HeJ MGP_C3HHeJ_G0019382
 protein coding gene Chr12:22669821-22763933 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020026
 protein coding gene Chr12:23382409-23472431 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017650
 protein coding gene Chr12:21525200-21613729 (+)
CAST/EiJ MGP_CASTEiJ_G0018937
 protein coding gene Chr12:17646482-17738312 (+)
CBA/J MGP_CBAJ_G0019353
 protein coding gene Chr12:24112420-24202649 (+)
DBA/2J MGP_DBA2J_G0019467
 protein coding gene Chr12:21898810-21986719 (+)
FVB/NJ MGP_FVBNJ_G0019458
 protein coding gene Chr12:21789847-21873842 (+)
LP/J MGP_LPJ_G0019537
 protein coding gene Chr12:22740486-22834375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019493
 protein coding gene Chr12:23976022-24069058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020065
 protein coding gene Chr12:22359186-22452280 (+)
PWK/PhJ MGP_PWKPhJ_G0018704
 protein coding gene Chr12:16641891-16728456 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018492
 protein coding gene Chr12:16858509-16949991 (+)
WSB/EiJ MGP_WSBEiJ_G0018988
 protein coding gene Chr12:22504411-22596931 (+)



Homology
more
  • Human Ortholog
    KIDINS220, kinase D interacting substrate 220
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIDINS220, kinase D interacting substrate 220
  • Synonyms
    ARMS, SINO, VENARG
  • Links
    NCBI Gene ID: 57498
    neXtProt AC: NX_Q9ULH0
    UniProt: Q9ULH0

  • Chr Location
    2p25.1; chr2:8721081-8837630 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele exhibit decreased dendritic complexity in the barrel somatosensory cortex and dentate gyrus neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    42
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036333 Ensembl Gene Model | MGI Sequence Detail 88228 C57BL/6J ±  kb
    transcript ENSMUST00000066652 Ensembl | MGI Sequence Detail 7409 Not Applicable  
    polypeptide ENSMUSP00000063999 Ensembl | MGI Sequence Detail 1793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR011646 KAP family P-loop domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 4
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1920401, MGI:2144771, MGI:2144787
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:323129 Del Puerto A, et al., Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation. Mol Psychiatry. 2021 Nov;26(11):6411-6426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory