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Rspo4 Gene Detail
Summary
  • Symbol
    Rspo4
  • Name
    R-spondin 4
  • Synonyms
    A930029K19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924467
    NCBI Gene: 228770
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151684847-151716588 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1110 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924467
 protein coding gene Chr2:151684571-151716588 (+)
129S1/SvImJ ENSMUSG00200027682
 protein coding gene Chr2:148590026-148622047 (+)
A/J ENSMUSG00195020961
 protein coding gene Chr2:148869379-148901412 (+)
AKR/J ENSMUSG00220042373
 protein coding gene Chr2:148192970-148224994 (+)
BALB/cJ ENSMUSG00180041955
 protein coding gene Chr2:148349106-148381131 (+)
C3H/HeJ ENSMUSG00175039815
 protein coding gene Chr2:149095375-149127398 (+)
C57BL/6NJ ENSMUSG00215017358
 protein coding gene Chr2:148527671-148559697 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024441
 protein coding gene Chr2:143742519-143774936 (+)
CAST/EiJ ENSTCUG00005040562
 protein coding gene Chr2:147463020-147495243 (+)
CBA/J ENSMUSG00210041640
 protein coding gene Chr2:149031895-149063920 (+)
DBA/2J ENSMUSG00185046966
 protein coding gene Chr2:148687702-148719728 (+)
FVB/NJ ENSMUSG00205022713
 protein coding gene Chr2:147788923-147820948 (+)
JF1/MsJ ENSUMUG00000044502
 protein coding gene Chr2:148374931-148407124 (+)
LP/J ENSMUSG00230033657
 protein coding gene Chr2:150342502-150374522 (+)
NOD/ShiLtJ ENSMUSG00190028363
 protein coding gene Chr2:148474599-148506786 (+)
NZO/HlLtJ ENSMUSG00225003452
 protein coding gene Chr2:158375858-158407881 (+)
PWK/PhJ ENSLUMG00010038663
 protein coding gene Chr2:148346463-148378757 (+)
SPRET/EiJ ENSMSPG00010025731
 protein coding gene Chr2:151068795-151100254 (+)
WSB/EiJ ENSIUOG00005041066
 protein coding gene Chr2:148205001-148237028 (+)



Homology
more
  • Human Ortholog
    RSPO4, R-spondin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSPO4, R-spondin 4
  • Synonyms
    C20orf182, CRISTIN4
  • Links
    NCBI Gene ID: 343637
    UniProt: Q2I0M5

  • Chr Location
    20p13; chr20:958452-1002372 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RSPO4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Rspo4
  • Find Mice (IMSR)
    12 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    263
  • cDNA Data
    14
  • Literature Summary
    26
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032852 Ensembl Gene Model | MGI Sequence Detail 31742 C57BL/6J ±  kb
transcript ENSMUST00000042217 Ensembl | MGI Sequence Detail 2371 Not Applicable  
polypeptide ENSMUSP00000041578 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 14
    Primer pair 5
    Other 3

    Microarray probesets 2
References
more
  • Summaries
    All 58
    Developmental Gene Expression 26
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory