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Klhl2 Gene Detail
Summary
  • Symbol
    Klhl2
  • Name
    kelch-like 2, Mayven
  • Synonyms
    6030411N21Rik, 8530402H02Rik, ABP-KELCH, Mav
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924363
    NCBI Gene: 77113
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:65192709-65302669 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 32.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    534 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924363
 protein coding gene Chr8:65192707-65302821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033644
 protein coding gene Chr8:64760210-64872346 (-)
A/J MGP_AJ_G0033626
 protein coding gene Chr8:62028923-62141828 (-)
AKR/J MGP_AKRJ_G0033551
 protein coding gene Chr8:63796792-63904878 (-)
BALB/cJ MGP_BALBcJ_G0033622
 protein coding gene Chr8:62312010-62422981 (-)
C3H/HeJ MGP_C3HHeJ_G0033332
 protein coding gene Chr8:64536681-64647145 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034139
 protein coding gene Chr8:67174476-67291012 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031086
 protein coding gene Chr8:57302447-57408470 (-)
CAST/EiJ MGP_CASTEiJ_G0032657
 protein coding gene Chr8:63986017-64096607 (-)
CBA/J MGP_CBAJ_G0033310
 protein coding gene Chr8:69685919-69801650 (-)
DBA/2J MGP_DBA2J_G0033464
 protein coding gene Chr8:61847640-61957556 (-)
FVB/NJ MGP_FVBNJ_G0033405
 protein coding gene Chr8:61066522-61174325 (-)
LP/J MGP_LPJ_G0033552
 protein coding gene Chr8:64798907-64912504 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033449
 protein coding gene Chr8:72237487-72353958 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034157
 protein coding gene Chr8:64092167-64203783 (-)
PWK/PhJ MGP_PWKPhJ_G0032366
 protein coding gene Chr8:61176340-61383839 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032202
 protein coding gene Chr8:63074643-63191731 (-)
WSB/EiJ MGP_WSBEiJ_G0032774
 protein coding gene Chr8:64477222-64585403 (-)



Homology
more
  • Human Ortholog
    KLHL2, kelch like family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL2, kelch like family member 2
  • Synonyms
    ABP-KELCH, MAV, MAYVEN
  • Links
    NCBI Gene ID: 11275
    neXtProt AC: NX_O95198
    UniProt: O95198

  • Chr Location
    4q32.3; chr4:165207561-165323156 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations are physically normal and do not exhibit hyperkalemia or metabolic acidosis, despite increased WNK4 protein levels in the kidney medulla.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031605 Ensembl Gene Model | MGI Sequence Detail 109961 C57BL/6J ±  kb
transcript ENSMUST00000210166 Ensembl | MGI Sequence Detail 5126 Not Applicable  
polypeptide ENSMUSP00000147262 Ensembl | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925485, MGI:2142725
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:47397 Soltysik-Espanola M, et al., Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 1999 Jul;10(7):2361-75
  • Latest
    J:250869 Kasagi Y, et al., Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. Biochem Biophys Res Commun. 2017 May 27;487(2):368-374
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory