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Mrap Gene Detail
Summary
  • Symbol
    Mrap
  • Name
    melanocortin 2 receptor accessory protein
  • Synonyms
    1110025G12Rik, C21ORF61
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924287
    NCBI Gene: 77037
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90535095-90546673 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.90 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924287
 protein coding gene Chr16:90535095-90546673 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023028
 protein coding gene Chr16:91702383-91716065 (+)
A/J MGP_AJ_G0022996
 protein coding gene Chr16:87424788-87437150 (+)
AKR/J MGP_AKRJ_G0022966
 protein coding gene Chr16:90058410-90069379 (+)
BALB/cJ MGP_BALBcJ_G0022998
 protein coding gene Chr16:87946264-87958328 (+)
C3H/HeJ MGP_C3HHeJ_G0022759
 protein coding gene Chr16:90621531-90637415 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023445
 protein coding gene Chr16:94681150-94698115 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020947
 protein coding gene Chr16:85125547-85137313 (+)
CAST/EiJ MGP_CASTEiJ_G0022278
 protein coding gene Chr16:91169402-91186140 (+)
CBA/J MGP_CBAJ_G0022728
 protein coding gene Chr16:98708276-98726164 (+)
DBA/2J MGP_DBA2J_G0022862
 protein coding gene Chr16:87324136-87335725 (+)
FVB/NJ MGP_FVBNJ_G0022836
 protein coding gene Chr16:86449680-86460917 (+)
LP/J MGP_LPJ_G0022932
 protein coding gene Chr16:91390867-91405492 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022857
 protein coding gene Chr16:103275713-103301374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023463
 protein coding gene Chr16:90568483-90579695 (+)
PWK/PhJ MGP_PWKPhJ_G0022023
 protein coding gene Chr16:87493854-87505638 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021853
 protein coding gene Chr16:90134168-90145647 (+)
WSB/EiJ MGP_WSBEiJ_G0022330
 protein coding gene Chr16:90804369-90817511 (+)



Homology
more
  • Human Ortholog
    MRAP, melanocortin 2 receptor accessory protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRAP, melanocortin 2 receptor accessory protein
  • Synonyms
    B27, C21orf61, FALP, FGD2, GCCD2, MRAP1
  • Links
    NCBI Gene ID: 56246
    neXtProt AC: NX_Q8TCY5
    UniProt: Q8TCY5

  • Chr Location
    21q22.11; chr21:32291813-32314784 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mrap mouse models; 1 with human MRAP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with failure of lungs to inflate, small adrenal glands, thickened adrenal casule due to hyperplasia and glucocorticoid deficiency symptoms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    29
  • cDNA Data
    34
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77037 NCBI Gene Model | MGI Sequence Detail 11579 C57BL/6J ±  kb
    transcript NR_155757 RefSeq | MGI Sequence Detail 1267 C57BL/6  
    polypeptide Q9D159 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 5
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 3
      Diseases 6
      Gene Ontology 4
      Phenotypes 80
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory