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Spopl Gene Detail
Summary
  • Symbol
    Spopl
  • Name
    speckle-type BTB/POZ protein-like
  • Synonyms
    4921517N04Rik, E430033K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924107
    NCBI Gene: 76857
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:23396232-23462118 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 15.48 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1604 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924107
 protein coding gene Chr2:23382942-23462139 (-)
129S1/SvImJ ENSMUSG00200051130
 protein coding gene Chr2:20374730-20440616 (-)
A/J ENSMUSG00195045330
 protein coding gene Chr2:20470659-20536534 (-)
AKR/J ENSMUSG00220048383
 protein coding gene Chr2:20598464-20664339 (-)
BALB/cJ ENSMUSG00180054152
 protein coding gene Chr2:20475934-20541822 (-)
C3H/HeJ ENSMUSG00175050657
 protein coding gene Chr2:20440478-20506370 (-)
C57BL/6NJ ENSMUSG00215046514
 protein coding gene Chr2:20500287-20566176 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023229
 protein coding gene Chr2:19477757-19539636 (-)
CAST/EiJ ENSTCUG00005051453
 protein coding gene Chr2:20209062-20274963 (-)
CBA/J ENSMUSG00210016845
 protein coding gene Chr2:20479429-20545319 (-)
DBA/2J ENSMUSG00185051629
 protein coding gene Chr2:20384972-20450847 (-)
FVB/NJ ENSMUSG00205026950
 protein coding gene Chr2:20398163-20464644 (-)
JF1/MsJ ENSUMUG00000053364
 protein coding gene Chr2:20298899-20356483 (-)
LP/J ENSMUSG00230035794
 protein coding gene Chr2:22310644-22376533 (-)
NOD/ShiLtJ ENSMUSG00190052149
 protein coding gene Chr2:20470841-20536720 (-)
NZO/HlLtJ ENSMUSG00225001259
 protein coding gene Chr2:30061301-30127187 (-)
PWK/PhJ ENSLUMG00010048906
 protein coding gene Chr2:20397665-20462096 (-)
SPRET/EiJ ENSMSPG00010029248
 protein coding gene Chr2:20999635-21060467 (-)
WSB/EiJ ENSIUOG00005047834
 protein coding gene Chr2:20281274-20350518 (-)



Homology
more
  • Human Ortholog
    SPOPL, speckle type BTB/POZ protein like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPOPL, speckle type BTB/POZ protein like
  • Synonyms
    BTBD33
  • Links
    NCBI Gene ID: 339745
    UniProt: Q6IQ16

  • Chr Location
    2q22.1; chr2:138501770-138574458 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with no gross morphological and skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    33
  • cDNA Data
    14
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026771 Ensembl Gene Model | MGI Sequence Detail 65887 C57BL/6J ±  kb
transcript ENSMUST00000132484 Ensembl | MGI Sequence Detail 6595 Not Applicable  
polypeptide ENSMUSP00000114974 Ensembl | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139149, MGI:2139449, MGI:2444012
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory