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Gper1 Gene Detail
Summary
  • Symbol
    Gper1
  • Name
    G protein-coupled estrogen receptor 1
  • Synonyms
    6330420K13Rik, Ceprl, CMKRL2, FEG-1, GPCR-Br, Gper, Gpr30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924104
    NCBI Gene: 76854
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139408906-139413555 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.58 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924104
 protein coding gene Chr5:139408905-139413555 (+)
129S1/SvImJ ENSMUSG00200039171
 protein coding gene Chr5:133277450-133282099 (+)
A/J ENSMUSG00195043182
 protein coding gene Chr5:132897968-132902617 (+)
AKR/J ENSMUSG00220021910
 protein coding gene Chr5:132160134-132164783 (+)
BALB/cJ ENSMUSG00180026947
 protein coding gene Chr5:132994410-132999059 (+)
C3H/HeJ ENSMUSG00175037852
 protein coding gene Chr5:134922692-134927341 (+)
C57BL/6NJ ENSMUSG00215037312
 protein coding gene Chr5:132853126-132857775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027934
 protein coding gene Chr5:132144365-132149025 (+)
CAST/EiJ ENSTCUG00005029525
 protein coding gene Chr5:132324402-132329014 (+)
CBA/J ENSMUSG00210022791
 protein coding gene Chr5:133739901-133744550 (+)
DBA/2J ENSMUSG00185050426
 protein coding gene Chr5:136755242-136759891 (+)
FVB/NJ ENSMUSG00205046727
 protein coding gene Chr5:132555193-132559842 (+)
JF1/MsJ ENSUMUG00000038457
 protein coding gene Chr5:139640286-139644923 (+)
LP/J ENSMUSG00230046433
 protein coding gene Chr5:140868232-140872881 (+)
NOD/ShiLtJ ENSMUSG00190038874
 protein coding gene Chr5:132694025-132698674 (+)
NZO/HlLtJ ENSMUSG00225021255
 protein coding gene Chr5:148341831-148346480 (+)
PWK/PhJ ENSLUMG00010017359
 protein coding gene Chr5:131368695-131373334 (+)
SPRET/EiJ ENSMSPG00010024198
 protein coding gene Chr5:134961979-134963330 (+)
WSB/EiJ ENSIUOG00005032582
 protein coding gene Chr5:135236722-135241371 (+)



Homology
more
  • Human Ortholog
    GPER1, G protein-coupled estrogen receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPER1, G protein-coupled estrogen receptor 1
  • Synonyms
    CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER
  • Links
    NCBI Gene ID: 2852
    UniProt: Q99527

  • Chr Location
    7p22.3; chr7:1082208-1094511 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 5 alleles in 5 genetic backgrounds
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit decreased thymic atrophy, insulin, and glucagon responses following treatment with PGE2.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    246
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053647 Ensembl Gene Model | MGI Sequence Detail 4650 C57BL/6J ±  kb
    transcript ENSMUST00000066211 Ensembl | MGI Sequence Detail 2537 Not Applicable  
    polypeptide ENSMUSP00000080370 Ensembl | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38426, MGI:109381
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 8
      Gene Ontology 14
      Phenotypes 66
    • Earliest
      J:38628 Feng Y, et al., Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. Biochem Biophys Res Commun. 1997 Feb 24;231(3):651-4
    • Latest
      J:382524 Venegas MA, et al., Estrogen signaling is necessary for the sex difference in simulated jet lag in mice. Am J Physiol Endocrinol Metab. 2025 Oct 1;329(4):E551-E559
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory