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Nubpl Gene Detail
Summary
  • Symbol
    Nubpl
  • Name
    nucleotide binding protein-like
  • Synonyms
    2410170E07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924076
    NCBI Gene: 76826
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:52144529-52357753 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.11 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924076
 protein coding gene Chr12:52144520-52359527 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019731
 protein coding gene Chr12:50929837-51140783 (+)
A/J MGP_AJ_G0019693
 protein coding gene Chr12:49119060-49320903 (+)
AKR/J MGP_AKRJ_G0019664
 protein coding gene Chr12:50601657-50823775 (+)
BALB/cJ MGP_BALBcJ_G0019671
 protein coding gene Chr12:49398525-49601521 (+)
C3H/HeJ MGP_C3HHeJ_G0019474
 protein coding gene Chr12:50695682-50913027 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020119
 protein coding gene Chr12:52501785-52716345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017742
 protein coding gene Chr12:47513366-47701501 (+)
CAST/EiJ MGP_CASTEiJ_G0019027
 protein coding gene Chr12:45754700-45951878 (+)
CBA/J MGP_CBAJ_G0019446
 protein coding gene Chr12:54291832-54512034 (+)
DBA/2J MGP_DBA2J_G0019560
 protein coding gene Chr12:48993385-49199061 (+)
FVB/NJ MGP_FVBNJ_G0019549
 protein coding gene Chr12:48430887-48634538 (+)
LP/J MGP_LPJ_G0019632
 protein coding gene Chr12:50971564-51176930 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019585
 protein coding gene Chr12:55908653-56158250 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020157
 protein coding gene Chr12:50101001-50313831 (+)
PWK/PhJ MGP_PWKPhJ_G0018794
 protein coding gene Chr12:43581017-43771441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018588
 protein coding gene Chr12:44700033-44894453 (+)
WSB/EiJ MGP_WSBEiJ_G0019078
 protein coding gene Chr12:50594818-50803128 (+)



Homology
more
  • Human Ortholog
    NUBPL, NUBP iron-sulfur cluster assembly factor, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUBPL, NUBP iron-sulfur cluster assembly factor, mitochondrial
  • Synonyms
    C14orf127, huInd1, IND1, MC1DN21
  • Links
    NCBI Gene ID: 80224
    neXtProt AC: NX_Q8TB37
    UniProt: Q8TB37

  • Chr Location
    14q12; chr14:31489956-31861224 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NUBPL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in placentation with abnormal trophoblast layer formation, abnormal trophoblast giant cell size and morphology, and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76826 NCBI Gene Model | MGI Sequence Detail 213225 C57BL/6J ±  kb
    transcript NM_029760 RefSeq | MGI Sequence Detail 1230 C57BL/6  
    polypeptide Q9CWD8 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011478 nucleotide-binding protein-like
      (term hierarchy)
    • InterPro Domains
      IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
      IPR000808 Iron-sulfur cluster carrier protein-like, conserved site
      IPR044304 Iron-sulfur protein NUBPL-like
      IPR019591 Mrp/NBP35 ATP-binding protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333699 Cheng C, et al., Early embryonic lethality in complex I associated p.L104P Nubpl mutant mice. Orphanet J Rare Dis. 2022 Oct 24;17(1):386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory