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Hectd3 Gene Detail
Summary
  • Symbol
    Hectd3
  • Name
    HECT domain E3 ubiquitin protein ligase 3
  • Synonyms
    1700064K09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923858
    NCBI Gene: 76608
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116852514-116862474 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923858
 protein coding gene Chr4:116852491-116862474 (+)
129S1/SvImJ ENSMUSG00200048089
 protein coding gene Chr4:110748828-110758789 (+)
A/J ENSMUSG00195032346
 protein coding gene Chr4:112014360-112024309 (+)
AKR/J ENSMUSG00220012242
 protein coding gene Chr4:111362581-111372544 (+)
BALB/cJ ENSMUSG00180043222
 protein coding gene Chr4:110082914-110092886 (+)
C3H/HeJ ENSMUSG00175039991
 protein coding gene Chr4:111097291-111107261 (+)
C57BL/6NJ ENSMUSG00215015126
 protein coding gene Chr4:112176764-112186725 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026347
 protein coding gene Chr4:107446334-107456782 (+)
CAST/EiJ ENSTCUG00005019307
 protein coding gene Chr4:110876686-110886667 (+)
CBA/J ENSMUSG00210052946
 protein coding gene Chr4:110710990-110720959 (+)
DBA/2J ENSMUSG00185046386
 protein coding gene Chr4:112239980-112249929 (+)
FVB/NJ ENSMUSG00205018331
 protein coding gene Chr4:110180350-110190322 (+)
JF1/MsJ ENSUMUG00000030489
 protein coding gene Chr4:112142365-112152328 (+)
LP/J ENSMUSG00230042239
 protein coding gene Chr4:115566074-115576034 (+)
NOD/ShiLtJ ENSMUSG00190046812
 protein coding gene Chr4:110079134-110089104 (+)
NZO/HlLtJ ENSMUSG00225011073
 protein coding gene Chr4:121054528-121064492 (+)
PWK/PhJ ENSLUMG00010043019
 protein coding gene Chr4:109540764-109550714 (+)
SPRET/EiJ ENSMSPG00010028502
 protein coding gene Chr4:111645933-111655887 (+)
WSB/EiJ ENSIUOG00005043494
 protein coding gene Chr4:110402096-110412044 (+)



Homology
more
  • Human Ortholog
    HECTD3, HECT domain E3 ubiquitin protein ligase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HECTD3, HECT domain E3 ubiquitin protein ligase 3
  • Links
    NCBI Gene ID: 79654
    UniProt: Q5T447

  • Chr Location
    1p34.1; chr1:45002540-45011369 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to intranasal bacterial infection due to suppressed bacterial intracellular replication.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046861 Ensembl Gene Model | MGI Sequence Detail 9961 C57BL/6J ±  kb
    transcript ENSMUST00000050067 Ensembl | MGI Sequence Detail 4583 Not Applicable  
    polypeptide ENSMUSP00000051922 Ensembl | MGI Sequence Detail 861 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140305, MGI:2140618
    References
    more
    • Summaries
      All 52
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:380242 Arratia LM, et al., Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of Na(V)1.2 and Na(V)1.6. Sci Rep. 2024 Mar 21;14(1):6761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory