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Gins4 Gene Detail
Summary
  • Symbol
    Gins4
  • Name
    GINS complex subunit 4
  • Synonyms
    2810037C03Rik, 4933405K01Rik, SLD5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923847
    NCBI Gene: 109145
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23716632-23727675 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923847
 protein coding gene Chr8:23716626-23727684 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033464
 protein coding gene Chr8:21130597-21144425 (-)
A/J MGP_AJ_G0033444
 protein coding gene Chr8:20426744-20437717 (-)
AKR/J MGP_AKRJ_G0033369
 protein coding gene Chr8:21100200-21111029 (-)
BALB/cJ MGP_BALBcJ_G0033440
 protein coding gene Chr8:20549190-20560445 (-)
C3H/HeJ MGP_C3HHeJ_G0033154
 protein coding gene Chr8:21295748-21307472 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033956
 protein coding gene Chr8:21996147-22008602 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030907
 protein coding gene Chr8:17765747-17775844 (-)
CAST/EiJ MGP_CASTEiJ_G0032480
 protein coding gene Chr8:20731528-20744079 (-)
CBA/J MGP_CBAJ_G0033129
 protein coding gene Chr8:22873438-22887312 (-)
DBA/2J MGP_DBA2J_G0033284
 protein coding gene Chr8:20396816-20408148 (-)
FVB/NJ MGP_FVBNJ_G0033228
 protein coding gene Chr8:20194355-20206321 (-)
LP/J MGP_LPJ_G0033373
 protein coding gene Chr8:21122627-21136231 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033271
 protein coding gene Chr8:22436140-22449514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033975
 protein coding gene Chr8:21006621-21017671 (-)
PWK/PhJ MGP_PWKPhJ_G0032192
 protein coding gene Chr8:19992317-20005405 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032025
 protein coding gene Chr8:20374160-20385875 (-)
WSB/EiJ MGP_WSBEiJ_G0032596
 protein coding gene Chr8:21210773-21221636 (-)



Homology
more
  • Human Ortholog
    GINS4, GINS complex subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GINS4, GINS complex subunit 4
  • Synonyms
    SLD5
  • Links
    NCBI Gene ID: 84296
    neXtProt AC: NX_Q9BRT9
    UniProt: Q9BRT9

  • Chr Location
    8p11.21; chr8:41529218-41545030 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals do not survive past implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    24
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031546 Ensembl Gene Model | MGI Sequence Detail 11044 C57BL/6J ±  kb
    transcript ENSMUST00000033950 Ensembl | MGI Sequence Detail 1349 Not Applicable  
    polypeptide ENSMUSP00000033950 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007985 DNA replication complex GINS protein SLD5
      (term hierarchy)
    • InterPro Domains
      IPR031633 DNA replication complex GINS protein SLD5, C-terminal
      IPR038749 GINS complex protein Sld5, alpha-helical domain
      IPR008591 GINS complex subunit Sld5
      IPR036224 GINS, helical bundle-like domain superfamily
      IPR021151 GINS subunit, domain A
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918260
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:299723 Kafer GR, et al., A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis. Front Cell Dev Biol. 2020;8:416
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory