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Wipi2 Gene Detail
Summary
  • Symbol
    Wipi2
  • Name
    WD repeat domain, phosphoinositide interacting 2
  • Synonyms
    1110018O08Rik, 2510001I10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923831
    NCBI Gene: 74781
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142615269-142655427 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    940 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923831
 protein coding gene Chr5:142613453-142656343 (+)
129S1/SvImJ ENSMUSG00200041058
 protein coding gene Chr5:136485506-136526580 (+)
A/J ENSMUSG00195039217
 protein coding gene Chr5:136126491-136167541 (+)
AKR/J ENSMUSG00220021947
 protein coding gene Chr5:135362847-135403940 (+)
BALB/cJ ENSMUSG00180026505
 protein coding gene Chr5:136228579-136269622 (+)
C3H/HeJ ENSMUSG00175043854
 protein coding gene Chr5:138154187-138195232 (+)
C57BL/6NJ ENSMUSG00215037345
 protein coding gene Chr5:136062715-136103761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027964
 protein coding gene Chr5:135365678-135407903 (+)
CAST/EiJ ENSTCUG00005027037
 protein coding gene Chr5:135507620-135548645 (+)
CBA/J ENSMUSG00210023054
 protein coding gene Chr5:136955556-136996631 (+)
DBA/2J ENSMUSG00185054040
 protein coding gene Chr5:139962283-140003370 (+)
FVB/NJ ENSMUSG00205037811
 protein coding gene Chr5:135784891-135825942 (+)
JF1/MsJ ENSUMUG00000022325
 protein coding gene Chr5:142834211-142875364 (+)
LP/J ENSMUSG00230024264
 protein coding gene Chr5:144089300-144130373 (+)
NOD/ShiLtJ ENSMUSG00190030087
 protein coding gene Chr5:135923913-135964956 (+)
NZO/HlLtJ ENSMUSG00225022361
 protein coding gene Chr5:151558182-151599227 (+)
PWK/PhJ ENSLUMG00010020084
 protein coding gene Chr5:134548003-134589048 (+)
SPRET/EiJ ENSMSPG00010024841
 protein coding gene Chr5:138164921-138202169 (+)
WSB/EiJ ENSIUOG00005036640
 protein coding gene Chr5:138447318-138488374 (+)



Homology
more
  • Human Ortholog
    WIPI2, WD repeat domain, phosphoinositide interacting 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WIPI2, WD repeat domain, phosphoinositide interacting 2
  • Synonyms
    ATG18B, Atg21, CGI-50, IDDSSA, WIPI-2
  • Links
    NCBI Gene ID: 26100
    UniProt: Q9Y4P8

  • Chr Location
    7p22.1; chr7:5190182-5233855 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    670
  • Tissues
    11
  • cDNA Data
    176
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74781 NCBI Gene Model | MGI Sequence Detail 40159 C57BL/6J ±  kb
    transcript NM_178398 RefSeq | MGI Sequence Detail 3942 C57BL/6  
    polypeptide Q80W47 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 176
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922031
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory