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Ift46 Gene Detail
Summary
  • Symbol
    Ift46
  • Name
    intraflagellar transport 46
  • Synonyms
    1500035H01Rik, IFT46
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923818
    NCBI Gene: 76568
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44683074-44704011 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923818
protein coding gene Chr9:44679205-44704744 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034718
protein coding gene Chr9:43302524-43322205 (+)
A/J MGP_AJ_G0034699
protein coding gene Chr9:42083808-42103558 (+)
AKR/J MGP_AKRJ_G0034626
protein coding gene Chr9:42945895-42977716 (+)
BALB/cJ MGP_BALBcJ_G0034690
protein coding gene Chr9:41823899-41843912 (+)
C3H/HeJ MGP_C3HHeJ_G0034401
protein coding gene Chr9:43407526-43427809 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035211
protein coding gene Chr9:44572035-44600510 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032126
protein coding gene Chr9:41644964-41664750 (+)
CAST/EiJ MGP_CASTEiJ_G0033723
protein coding gene Chr9:43269410-43289037 (+)
CBA/J MGP_CBAJ_G0034373
protein coding gene Chr9:46200645-46230531 (+)
DBA/2J MGP_DBA2J_G0034532
protein coding gene Chr9:41981558-42001230 (+)
FVB/NJ MGP_FVBNJ_G0034473
protein coding gene Chr9:41237990-41262480 (+)
LP/J MGP_LPJ_G0034613
protein coding gene Chr9:43600923-43622198 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034517
protein coding gene Chr9:48041803-48073111 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035232
protein coding gene Chr9:42879215-42899885 (+)
PWK/PhJ MGP_PWKPhJ_G0033428
protein coding gene Chr9:41867116-41887005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033264
protein coding gene Chr9:43174617-43195309 (+)
WSB/EiJ MGP_WSBEiJ_G0033836
protein coding gene Chr9:42894976-42921441 (+)



Homology
more
  • Human Ortholog
    IFT46, intraflagellar transport 46
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT46, intraflagellar transport 46
  • Synonyms
    C11orf2, C11orf60, CFAP32, FAP32
  • Links
    NCBI Gene ID: 56912
    neXtProt AC: NX_Q9NQC8
    UniProt: Q9NQC8

  • Chr Location
    11q23.3; chr11:118544528-118576898 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are embryonic lethal at E10.5 and exhibit embryonic growth retardation, neural tube defects, cardiac edema, and randomized heart looping due to absence of cilia at the embryonic node.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76568 NCBI Gene Model | MGI Sequence Detail 20938 C57BL/6J ±  kb
    transcript NM_023831 RefSeq | MGI Sequence Detail 3337 C57BL/6  
    polypeptide Q9DB07 UniProt | EBI | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 105
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142918, MGI:2143111, MGI:2143447
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 8
    • Earliest
      J:74598 O'Brien KP, et al., Characterization of five novel human genes in the 11q13-q22 region. Biochem Biophys Res Commun. 2000 Jun 24;273(1):90-4
    • Latest
      J:299747 Lee EJ, et al., Autophagy induction promotes renal cyst growth in polycystic kidney disease. EBioMedicine. 2020 Oct;60:102986

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory