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Lhpp Gene Detail
Summary
  • Symbol
    Lhpp
  • Name
    phospholysine phosphohistidine inorganic pyrophosphate phosphatase
  • Synonyms
    2310007H09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923679
    NCBI Gene: 76429
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132212367-132308149 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 76.30 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2936 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923679
 protein coding gene Chr7:132212344-132308149 (+)
129S1/SvImJ ENSMUSG00200025659
 protein coding gene Chr7:118746921-118842909 (+)
A/J ENSMUSG00195040995
 protein coding gene Chr7:123218254-123314245 (+)
AKR/J ENSMUSG00220016367
 protein coding gene Chr7:116679743-116775722 (+)
BALB/cJ ENSMUSG00180011777
 protein coding gene Chr7:119923778-120019765 (+)
C3H/HeJ ENSMUSG00175018338
 protein coding gene Chr7:120650112-120746089 (+)
C57BL/6NJ ENSMUSG00215014337
 protein coding gene Chr7:119928391-120024376 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030579
 protein coding gene Chr7:134809945-134906679 (+)
CAST/EiJ ENSTCUG00005048685
 protein coding gene Chr7:123230207-123334916 (+)
CBA/J ENSMUSG00210023350
 protein coding gene Chr7:120412051-120508031 (+)
DBA/2J ENSMUSG00185023306
 protein coding gene Chr7:124728316-124824289 (+)
FVB/NJ ENSMUSG00205036756
 protein coding gene Chr7:120363413-120459389 (+)
JF1/MsJ ENSUMUG00000047056
 protein coding gene Chr7:129738902-129837852 (+)
LP/J ENSMUSG00230052516
 protein coding gene Chr7:130853585-130949393 (+)
NOD/ShiLtJ ENSMUSG00190015031
 protein coding gene Chr7:120552215-120648190 (+)
NZO/HlLtJ ENSMUSG00225012467
 protein coding gene Chr7:129085727-129181699 (+)
PWK/PhJ ENSLUMG00010039114
 protein coding gene Chr7:118931652-119029661 (+)
SPRET/EiJ ENSMSPG00010011377
 protein coding gene Chr7:120238494-120334113 (+)
WSB/EiJ ENSIUOG00005028907
 protein coding gene Chr7:121242818-121338756 (+)



Homology
more
  • Human Ortholog
    LHPP, phospholysine phosphohistidine inorganic pyrophosphate phosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LHPP, phospholysine phosphohistidine inorganic pyrophosphate phosphatase
  • Synonyms
    HDHD2B
  • Links
    NCBI Gene ID: 64077
    UniProt: Q9H008

  • Chr Location
    10q26.13; chr10:124461792-124617888 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Global or astrocyte-specific knockout or a p.E56K mutation leads to resistance to depression-like behavior after chronic unpredictable stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    704
  • Tissues
    104
  • cDNA Data
    34
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030946 Ensembl Gene Model | MGI Sequence Detail 95783 C57BL/6J ±  kb
transcript ENSMUST00000033241 Ensembl | MGI Sequence Detail 1612 Not Applicable  
polypeptide ENSMUSP00000033241 Ensembl | MGI Sequence Detail 270 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:347874 Zhuang L, et al., LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates Depression-like Behavior by Dephosphorylating CaMKIIalpha and ERK. Biol Psychiatry. 2024 Mar 1;95(5):389-402
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory