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Det1 Gene Detail
Summary
  • Symbol
    Det1
  • Name
    DET1 partner of COP1 E3 ubiquitin ligase
  • Synonyms
    2610034H20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923625
    NCBI Gene: 76375
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78471295-78497011 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 44.81 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    574 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923625
 protein coding gene Chr7:78471293-78497272 (-)
129S1/SvImJ ENSMUSG00200030730
 protein coding gene Chr7:65291768-65317332 (-)
A/J ENSMUSG00195013843
 protein coding gene Chr7:69708811-69734516 (-)
AKR/J ENSMUSG00220033399
 protein coding gene Chr7:63250803-63276503 (-)
BALB/cJ ENSMUSG00180012018
 protein coding gene Chr7:66433921-66459622 (-)
C3H/HeJ ENSMUSG00175021400
 protein coding gene Chr7:67203825-67229387 (-)
C57BL/6NJ ENSMUSG00215027564
 protein coding gene Chr7:66295680-66321397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029871
 protein coding gene Chr7:81378530-81401352 (-)
CAST/EiJ ENSTCUG00005003954
 protein coding gene Chr7:69753821-69777338 (-)
CBA/J ENSMUSG00210023477
 protein coding gene Chr7:67055151-67080715 (-)
DBA/2J ENSMUSG00185045287
 protein coding gene Chr7:71377871-71403437 (-)
FVB/NJ ENSMUSG00205017508
 protein coding gene Chr7:66930809-66956074 (-)
JF1/MsJ ENSUMUG00000016057
 protein coding gene Chr7:76026386-76051455 (-)
LP/J ENSMUSG00230010965
 protein coding gene Chr7:77469728-77495423 (-)
NOD/ShiLtJ ENSMUSG00190016020
 protein coding gene Chr7:67198603-67224306 (-)
NZO/HlLtJ ENSMUSG00225041405
 protein coding gene Chr7:75706860-75730484 (-)
PWK/PhJ ENSLUMG00010015741
 protein coding gene Chr7:65618682-65646159 (-)
SPRET/EiJ ENSMSPG00010021132
 protein coding gene Chr7:66040958-66065340 (-)
WSB/EiJ ENSIUOG00005020301
 protein coding gene Chr7:67546691-67571330 (-)



Homology
more
  • Human Ortholog
    DET1, DET1 partner of COP1 E3 ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DET1, DET1 partner of COP1 E3 ubiquitin ligase
  • Links
    NCBI Gene ID: 55070
    UniProt: Q7L5Y6

  • Chr Location
    15q26.1; chr15:88494440-88547321 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030610 Ensembl Gene Model | MGI Sequence Detail 25717 C57BL/6J ±  kb
    transcript ENSMUST00000032839 Ensembl | MGI Sequence Detail 2269 Not Applicable  
    polypeptide ENSMUSP00000032839 Ensembl | MGI Sequence Detail 550 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:379135 Karayel O, et al., Impairment of DET1 causes neurological defects and lethality in mice and humans. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2422631122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory