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Slc18b1 Gene Detail
Summary
  • Symbol
    Slc18b1
  • Name
    solute carrier family 18, subfamily B, member 1
  • Synonyms
    1110021L09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923556
    NCBI Gene: 76306
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:23672884-23703866 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 11.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1019 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923556
 protein coding gene Chr10:23672876-23703867 (+)
129S1/SvImJ ENSMUSG00200008551
 protein coding gene Chr10:20510984-20541971 (+)
A/J ENSMUSG00195013076
 protein coding gene Chr10:20832264-20841159 (+)
AKR/J ENSMUSG00220010606
 protein coding gene Chr10:20512539-20543566 (+)
BALB/cJ ENSMUSG00180015816
 protein coding gene Chr10:20955522-20964418 (+)
C3H/HeJ ENSMUSG00175023741
 protein coding gene Chr10:20629458-20638354 (+)
C57BL/6NJ ENSMUSG00215011480
 protein coding gene Chr10:20460664-20491653 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015172
 protein coding gene Chr10:19827223-19858057 (+)
CAST/EiJ ENSTCUG00005013423
 protein coding gene Chr10:20230751-20261476 (+)
CBA/J ENSMUSG00210023306
 protein coding gene Chr10:20577068-20608054 (+)
DBA/2J ENSMUSG00185006436
 protein coding gene Chr10:20747087-20755950 (+)
FVB/NJ ENSMUSG00205008959
 protein coding gene Chr10:20774511-20805548 (+)
JF1/MsJ ENSUMUG00000012609
 protein coding gene Chr10:20554100-20584733 (+)
LP/J ENSMUSG00230009371
 protein coding gene Chr10:22545618-22576600 (+)
NOD/ShiLtJ ENSMUSG00190014647
 protein coding gene Chr10:20884636-20893503 (+)
NZO/HlLtJ ENSMUSG00225029511
 protein coding gene Chr10:26799932-26830919 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010014697
 protein coding gene Chr10:21150410-21180198 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SLC18B1, solute carrier family 18 member B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC18B1, solute carrier family 18 member B1
  • Synonyms
    C6orf192, dJ55C23.6, VPAT
  • Links
    NCBI Gene ID: 116843
    UniProt: Q6NT16

  • Chr Location
    6q23.2; chr6:132769370-132813339 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    10
  • Targeted
    2
  • Genomic Mutations
    1 involving Slc18b1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    33 strains or lines available
Mice homozygous for a conditional allele ubiquitously activated exhibit reduced brain polyamine levels, impaired memory and altered response to addictive substances.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    23
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037455 Ensembl Gene Model | MGI Sequence Detail 30983 C57BL/6J ±  kb
transcript ENSMUST00000119597 Ensembl | MGI Sequence Detail 2837 Not Applicable  
polypeptide ENSMUSP00000112634 Ensembl | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory