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Nkain2 Gene Detail
Summary
  • Symbol
    Nkain2
  • Name
    Na+/K+ transporting ATPase interacting 2
  • Synonyms
    6330571D19Rik, Tcba1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923447
    NCBI Gene: 432450
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:31565306-32766458 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 17.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34424 from dbSNP Build 142
  • Strain Annotations
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923447
 protein coding gene Chr10:31565306-32773170 (-)
129S1/SvImJ ENSMUSG00200008268
 protein coding gene Chr10:28414468-29608410 (-)
129S1/SvImJ ENSMUSG00200008297
 protein coding gene Chr10:29608390-29608947 (-)
A/J ENSMUSG00195014173
 protein coding gene Chr10:29886573-29887130 (-)
A/J ENSMUSG00195014156
 protein coding gene Chr10:28692487-29886593 (-)
AKR/J ENSMUSG00220010536
 protein coding gene Chr10:29574758-29575315 (-)
AKR/J ENSMUSG00220010529
 protein coding gene Chr10:28375812-29574778 (-)
BALB/cJ ENSMUSG00180017052
 protein coding gene Chr10:30006650-30007207 (-)
BALB/cJ ENSMUSG00180017029
 protein coding gene Chr10:28812602-30006670 (-)
C3H/HeJ ENSMUSG00175023850
 protein coding gene Chr10:29761575-29762132 (-)
C3H/HeJ ENSMUSG00175023815
 protein coding gene Chr10:28567576-29761595 (-)
C57BL/6NJ ENSMUSG00215010381
 protein coding gene Chr10:29549811-29550368 (-)
C57BL/6NJ ENSMUSG00215010287
 protein coding gene Chr10:28355860-29549831 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015219
 protein coding gene Chr10:27438880-28674549 (-)
CAST/EiJ ENSTCUG00005013763
 protein coding gene Chr10:28227747-29385443 (-)
CBA/J ENSMUSG00210023134
 protein coding gene Chr10:29689069-29689626 (-)
CBA/J ENSMUSG00210023127
 protein coding gene Chr10:28495118-29689089 (-)
DBA/2J ENSMUSG00185006589
 protein coding gene Chr10:29841889-29842446 (-)
DBA/2J ENSMUSG00185006572
 protein coding gene Chr10:28647885-29841909 (-)
FVB/NJ ENSMUSG00205009487
 protein coding gene Chr10:29837068-29837625 (-)
FVB/NJ ENSMUSG00205009470
 protein coding gene Chr10:28629154-29837088 (-)
JF1/MsJ ENSUMUG00000011308
 protein coding gene Chr10:28515993-29690104 (-)
LP/J ENSMUSG00230014839
 protein coding gene Chr10:30413488-31607472 (-)
LP/J ENSMUSG00230014854
 protein coding gene Chr10:31607452-31608009 (-)
NOD/ShiLtJ ENSMUSG00190014883
 protein coding gene Chr10:28759448-29954916 (-)
NOD/ShiLtJ ENSMUSG00190014896
 protein coding gene Chr10:29954896-29955453 (-)
NZO/HlLtJ ENSMUSG00225033321
 protein coding gene Chr10:34671883-35865852 (-)
NZO/HlLtJ ENSMUSG00225033345
 protein coding gene Chr10:35865832-35866389 (-)
PWK/PhJ ENSLUMG00010009176
 protein coding gene Chr10:28340233-29504824 (-)
SPRET/EiJ ENSMSPG00010014933
 protein coding gene Chr10:29383157-30545304 (-)
WSB/EiJ ENSIUOG00005029443
 protein coding gene Chr10:28186653-29397721 (-)



Homology
more
  • Human Ortholog
    NKAIN2, sodium/potassium transporting ATPase interacting 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKAIN2, sodium/potassium transporting ATPase interacting 2
  • Synonyms
    FAM77B, NKAIP2, TCBA, TCBA1
  • Links
    NCBI Gene ID: 154215
    UniProt: Q5VXU1

  • Chr Location
    6q22.31; chr6:123803865-124825640 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NKAIN2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nkain2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    25 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069670 Ensembl Gene Model | MGI Sequence Detail 1201153 C57BL/6J ±  kb
transcript ENSMUST00000218645 Ensembl | MGI Sequence Detail 703 Not Applicable  
polypeptide ENSMUSP00000151255 Ensembl | MGI Sequence Detail 213 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011227 sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
    (term hierarchy)
  • InterPro Domains
    IPR008516 Na,K-Atpase Interacting protein
  • GlyGen
    Q4PNJ2 2 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143838
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:231433 Xiao J, et al., Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Exp Neurol. 2016 Sep;283(Pt A):110-20
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory