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Adad2 Gene Detail
Summary
  • Symbol
    Adad2
  • Name
    adenosine deaminase domain containing 2
  • Synonyms
    4930403J07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923023
    NCBI Gene: 75773
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120339486-120343663 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 68.05 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923023
 protein coding gene Chr8:120339449-120343665 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034188
 protein coding gene Chr8:122951710-122958392 (+)
A/J MGP_AJ_G0034168
 protein coding gene Chr8:117887130-117891310 (+)
AKR/J MGP_AKRJ_G0034095
 protein coding gene Chr8:121311214-121315394 (+)
BALB/cJ MGP_BALBcJ_G0034162
 protein coding gene Chr8:118091283-118095463 (+)
C3H/HeJ MGP_C3HHeJ_G0033873
 protein coding gene Chr8:122037029-122041209 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034682
 protein coding gene Chr8:127061959-127066139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031624
 protein coding gene Chr8:110781998-110786469 (+)
CAST/EiJ MGP_CASTEiJ_G0033200
 protein coding gene Chr8:121981013-121987158 (+)
CBA/J MGP_CBAJ_G0033846
 protein coding gene Chr8:131685379-131689559 (+)
DBA/2J MGP_DBA2J_G0034002
 protein coding gene Chr8:117107101-117111281 (+)
FVB/NJ MGP_FVBNJ_G0033945
 protein coding gene Chr8:116138265-116142445 (+)
LP/J MGP_LPJ_G0034091
 protein coding gene Chr8:123091958-123096138 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033992
 protein coding gene Chr8:134128201-134132412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034700
 protein coding gene Chr8:121462501-121466681 (+)
PWK/PhJ MGP_PWKPhJ_G0032902
 protein coding gene Chr8:116861428-116865744 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032742
 protein coding gene Chr8:120155133-120159363 (+)
WSB/EiJ MGP_WSBEiJ_G0033316
 protein coding gene Chr8:122179388-122183577 (+)



Homology
more
  • Human Ortholog
    ADAD2, adenosine deaminase domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAD2, adenosine deaminase domain containing 2
  • Synonyms
    TENRL
  • Links
    NCBI Gene ID: 161931
    neXtProt AC: NX_Q8NCV1
    UniProt: Q8NCV1

  • Chr Location
    16q24.1; chr16:84191138-84197168 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 6 alleles in 6 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations of this gene exhibit male infertility associated with arrested spermiogenesis and instability of P-bodies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    33
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024266 Ensembl Gene Model | MGI Sequence Detail 4178 C57BL/6J ±  kb
    transcript ENSMUST00000098361 Ensembl | MGI Sequence Detail 1926 Not Applicable  
    polypeptide ENSMUSP00000095964 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:337548 Lu Y, et al., ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Andrology. 2023 May;11(4):698-709
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory