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Cul5 Gene Detail
Summary
  • Symbol
    Cul5
  • Name
    cullin 5
  • Synonyms
    4921514I20Rik, 8430423K24Rik, C030032G03Rik, C330021I08Rik, VACM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922967
    NCBI Gene: 75717
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:53525881-53578807 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.12 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1275 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922967
 protein coding gene Chr9:53525881-53581314 (-)
129S1/SvImJ ENSMUSG00200018032
 protein coding gene Chr9:50657055-50709974 (-)
A/J ENSMUSG00195019043
 protein coding gene Chr9:50362278-50415203 (-)
AKR/J ENSMUSG00220028274
 protein coding gene Chr9:50483639-50536566 (-)
BALB/cJ ENSMUSG00180030899
 protein coding gene Chr9:50475631-50528551 (-)
C3H/HeJ ENSMUSG00175013118
 protein coding gene Chr9:50487569-50540488 (-)
C57BL/6NJ ENSMUSG00215012953
 protein coding gene Chr9:50459096-50512034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032219
 protein coding gene Chr9:50397868-50443908 (-)
CAST/EiJ ENSTCUG00005013513
 protein coding gene Chr9:50406712-50459447 (-)
CBA/J ENSMUSG00210016323
 protein coding gene Chr9:50598248-50651155 (-)
DBA/2J ENSMUSG00185010166
 protein coding gene Chr9:50616088-50669251 (-)
FVB/NJ ENSMUSG00205016635
 protein coding gene Chr9:50879867-50932794 (-)
JF1/MsJ ENSUMUG00000039935
 protein coding gene Chr9:50649002-50700301 (-)
LP/J ENSMUSG00230040924
 protein coding gene Chr9:50868351-50921273 (-)
NOD/ShiLtJ ENSMUSG00190020434
 protein coding gene Chr9:50677960-50730879 (-)
NZO/HlLtJ ENSMUSG00225027828
 protein coding gene Chr9:50872451-50925375 (-)
PWK/PhJ ENSLUMG00010019930
 protein coding gene Chr9:50608051-50660737 (-)
SPRET/EiJ ENSMSPG00010022683
 protein coding gene Chr9:51537068-51587986 (-)
WSB/EiJ ENSIUOG00005017181
 protein coding gene Chr9:50091553-50144503 (-)



Homology
more
  • Human Ortholog
    CUL5, cullin 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUL5, cullin 5
  • Synonyms
    CUL-5, VACM-1, VACM1
  • Links
    NCBI Gene ID: 8065
    UniProt: Q93034

  • Chr Location
    11q22.3; chr11:108008898-108107781 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete embryonic lethality. Mice heterozygous for a null allele exhibit decreased susceptibility to LPS-induced lung injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    294
  • cDNA Data
    22
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75717 NCBI Gene Model | MGI Sequence Detail 52927 C57BL/6J ±  kb
    transcript NM_027807 RefSeq | MGI Sequence Detail 6024 C57BL/6  
    polypeptide Q9D5V5 UniProt | EBI | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1918729, MGI:1924813, MGI:1925779, MGI:2143157
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 10
      Gene Ontology 14
      Phenotypes 13
    • Earliest
      J:38757 Byrd PJ, et al., Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23 [letter]. Genome Res. 1997 Jan;7(1):71-5
    • Latest
      J:370522 Kauppi M, et al., Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice. Blood. 2025 Mar 6;145(10):1034-1046
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory