About   Help   FAQ
Ippk Gene Detail
Summary
  • Symbol
    Ippk
  • Name
    inositol 1,3,4,5,6-pentakisphosphate 2-kinase
  • Synonyms
    1810043M15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922928
    NCBI Gene: 75678
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:49574725-49618049 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 25.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922928
 protein coding gene Chr13:49574673-49618050 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020535
 protein coding gene Chr13:48395555-48439240 (+)
A/J MGP_AJ_G0020489
 protein coding gene Chr13:46675093-46716198 (+)
AKR/J MGP_AKRJ_G0020466
 protein coding gene Chr13:47994666-48039724 (+)
BALB/cJ MGP_BALBcJ_G0020485
 protein coding gene Chr13:46893893-46936632 (+)
C3H/HeJ MGP_C3HHeJ_G0020284
 protein coding gene Chr13:47817331-47863540 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020918
 protein coding gene Chr13:49849940-49895063 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018503
 protein coding gene Chr13:44652524-44693276 (+)
CAST/EiJ MGP_CASTEiJ_G0019799
 protein coding gene Chr13:47823272-47871183 (+)
CBA/J MGP_CBAJ_G0020245
 protein coding gene Chr13:51912233-51960803 (+)
DBA/2J MGP_DBA2J_G0020367
 protein coding gene Chr13:46201644-46243183 (+)
FVB/NJ MGP_FVBNJ_G0020346
 protein coding gene Chr13:45724669-45769310 (+)
LP/J MGP_LPJ_G0020442
 protein coding gene Chr13:48617373-48662964 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020375
 protein coding gene Chr13:51620826-51665136 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020961
 protein coding gene Chr13:47693788-47737469 (+)
PWK/PhJ MGP_PWKPhJ_G0019555
 protein coding gene Chr13:46385119-46427941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019383
 protein coding gene Chr13:46401126-46444333 (+)
WSB/EiJ MGP_WSBEiJ_G0019861
 protein coding gene Chr13:48009089-48054826 (+)



Homology
more
  • Human Ortholog
    IPPK, inositol-pentakisphosphate 2-kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IPPK, inositol-pentakisphosphate 2-kinase
  • Synonyms
    bA476B13.1, C9orf12, INSP5K2, IP5K, IPK1
  • Links
    NCBI Gene ID: 64768
    neXtProt AC: NX_Q9H8X2
    UniProt: Q9H8X2

  • Chr Location
    9q22.31; chr9:92613183-92670131 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trap insertion die prior to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    150
  • cDNA Data
    44
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021385 Ensembl Gene Model | MGI Sequence Detail 43325 C57BL/6J ±  kb
    transcript ENSMUST00000021817 Ensembl | MGI Sequence Detail 2856 Not Applicable  
    polypeptide ENSMUSP00000021817 Ensembl | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:245612 Franco-Echevarria E, et al., The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function. J Biol Chem. 2017 Jun 23;292(25):10534-10548
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory