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Pabpc1l Gene Detail
Summary
  • Symbol
    Pabpc1l
  • Name
    poly(A) binding protein, cytoplasmic 1-like
  • Synonyms
    1810053B01Rik, ePAB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922908
    NCBI Gene: 381404
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163867370-163892458 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922908
 protein coding gene Chr2:163866685-163892458 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026834
 protein coding gene Chr2:169395530-169429657 (+)
A/J MGP_AJ_G0026800
 protein coding gene Chr2:162547738-162575318 (+)
AKR/J MGP_AKRJ_G0026771
 protein coding gene Chr2:167365567-167391025 (+)
BALB/cJ MGP_BALBcJ_G0026809
 protein coding gene Chr2:162889885-162915259 (+)
C3H/HeJ MGP_C3HHeJ_G0026551
 protein coding gene Chr2:167713045-167741172 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027257
 protein coding gene Chr2:174332996-174372137 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024627
 protein coding gene Chr2:155852156-155878593 (+)
CAST/EiJ MGP_CASTEiJ_G0026012
 protein coding gene Chr2:168127464-168154693 (+)
CBA/J MGP_CBAJ_G0026528
 protein coding gene Chr2:180611321-180644698 (+)
DBA/2J MGP_DBA2J_G0026666
 protein coding gene Chr2:161717641-161743415 (+)
FVB/NJ MGP_FVBNJ_G0026632
 protein coding gene Chr2:160093925-160121627 (+)
LP/J MGP_LPJ_G0026769
 protein coding gene Chr2:169506638-169537308 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026654
 protein coding gene Chr2:184279059-184311018 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027313
 protein coding gene Chr2:167258334-167292922 (+)
PWK/PhJ MGP_PWKPhJ_G0025746
 protein coding gene Chr2:161289209-161316462 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025549
 protein coding gene Chr2:166139781-166170223 (+)
WSB/EiJ MGP_WSBEiJ_G0026082
 protein coding gene Chr2:168123458-168151539 (+)



Homology
more
  • Human Ortholog
    PABPC1L, poly(A) binding protein cytoplasmic 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PABPC1L, poly(A) binding protein cytoplasmic 1 like
  • Synonyms
    C20orf119, dJ1069P2.3, EPAB, PABPC1L1
  • Links
    NCBI Gene ID: 80336
    UniProt: Q4VXU2

  • Chr Location
    chr20:44910060-44959035 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired oocyte maturation and female infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    29
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054582 Ensembl Gene Model | MGI Sequence Detail 25089 C57BL/6J ±  kb
    transcript ENSMUST00000067715 Ensembl | MGI Sequence Detail 2354 Not Applicable  
    polypeptide ENSMUSP00000096701 Ensembl | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR036053 PABC (PABP) domain
      IPR034364 PABP, RNA recognition motif 1
      IPR045305 PABP, RNA recognition motif 2
      IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
      IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR003954 RNA recognition motif domain, eukaryote
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 12
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:336445 Wang W, et al., Bi-allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility. EMBO Mol Med. 2023 Jun 7;15(6):e17177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory