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Cklf Gene Detail
Summary
  • Symbol
    Cklf
  • Name
    chemokine-like factor
  • Synonyms
    1700001C14Rik, A730028G07Rik, C32, chemokine-like factor 4, CKLF1, CKLF2, CKLF3, CKLF4, CKLF5, Cklf6, HSPC224, UCK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922708
    NCBI Gene: 75458
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:104977493-104991570 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922708
protein coding gene Chr8:104977493-104992642 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034003
protein coding gene Chr8:106364884-106385888 (+)
A/J MGP_AJ_G0033984
protein coding gene Chr8:102140078-102155241 (+)
AKR/J MGP_AKRJ_G0033911
protein coding gene Chr8:105099597-105114429 (+)
BALB/cJ MGP_BALBcJ_G0033977
protein coding gene Chr8:102371170-102383615 (+)
C3H/HeJ MGP_C3HHeJ_G0033689
protein coding gene Chr8:105797577-105816400 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034498
protein coding gene Chr8:110270157-110285613 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031441
protein coding gene Chr8:95451789-95464603 (+)
CAST/EiJ MGP_CASTEiJ_G0033019
protein coding gene Chr8:105376295-105397224 (+)
CBA/J MGP_CBAJ_G0033663
protein coding gene Chr8:113898421-113919088 (+)
DBA/2J MGP_DBA2J_G0033817
protein coding gene Chr8:101505510-101522689 (+)
FVB/NJ MGP_FVBNJ_G0033764
protein coding gene Chr8:100443458-100458044 (+)
LP/J MGP_LPJ_G0033908
protein coding gene Chr8:106547688-106569163 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033806
protein coding gene Chr8:117091051-117100118 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0032720
protein coding gene Chr8:100917022-100932874 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032558
protein coding gene Chr8:103891342-103907839 (+)
WSB/EiJ MGP_WSBEiJ_G0033132
protein coding gene Chr8:105736629-105751253 (+)



Homology
more
  • Human Ortholog
    CKLF, chemokine like factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKLF, chemokine like factor
  • Synonyms
    C32, CKLF1, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1
  • Links
    NCBI Gene ID: 51192
    neXtProt AC: NX_Q9UBR5
    UniProt: Q9UBR5

  • Chr Location
    16q21; chr16:66552563-66566287 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete preweaning lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054400 Ensembl Gene Model | MGI Sequence Detail 14078 C57BL/6J ±  kb
transcript ENSMUST00000034342 Ensembl | MGI Sequence Detail 667 Not Applicable  
polypeptide ENSMUSP00000034342 Ensembl | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 13
Other
Accession IDs
less
MGI:2443587
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:335273 Ma WY, et al., A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. J Neuroinflammation. 2023 Apr 25;20(1):97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory