About   Help   FAQ
Mphosph8 Gene Detail
Summary
  • Symbol
    Mphosph8
  • Name
    M-phase phosphoprotein 8
  • Synonyms
    1500035L22Rik, 4930548G07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922589
    NCBI Gene: 75339
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56905705-56934887 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922589
protein coding gene Chr14:56905692-56934887 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021396
protein coding gene Chr14:50762868-50793047 (+)
A/J MGP_AJ_G0021355
protein coding gene Chr14:49753054-49782194 (+)
AKR/J MGP_AKRJ_G0021331
protein coding gene Chr14:51559310-51588411 (+)
BALB/cJ MGP_BALBcJ_G0021358
protein coding gene Chr14:49743758-49773105 (+)
C3H/HeJ MGP_C3HHeJ_G0021139
protein coding gene Chr14:51197660-51226784 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021798
protein coding gene Chr14:53290922-53323298 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019340
protein coding gene Chr14:47911198-47943379 (+)
CAST/EiJ MGP_CASTEiJ_G0020658
protein coding gene Chr14:47521934-47551543 (+)
CBA/J MGP_CBAJ_G0021106
protein coding gene Chr14:54874940-54906796 (+)
DBA/2J MGP_DBA2J_G0021226
protein coding gene Chr14:49469604-49499243 (+)
FVB/NJ MGP_FVBNJ_G0021209
protein coding gene Chr14:48863966-48893068 (+)
LP/J MGP_LPJ_G0021301
protein coding gene Chr14:51832882-51863243 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021233
protein coding gene Chr14:54267488-54296944 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021824
protein coding gene Chr14:50690099-50719115 (+)
PWK/PhJ MGP_PWKPhJ_G0020401
protein coding gene Chr14:45991896-46021531 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020231
protein coding gene Chr14:46751602-46778426 (+)
WSB/EiJ MGP_WSBEiJ_G0020710
protein coding gene Chr14:51028020-51057014 (+)



Homology
more
  • Human Ortholog
    MPHOSPH8, M-phase phosphoprotein 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPHOSPH8, M-phase phosphoprotein 8
  • Synonyms
    HSMPP8, mpp8, TWA3
  • Links
    NCBI Gene ID: 54737
    neXtProt AC: NX_Q99549
    UniProt: Q99549

  • Chr Location
    13q12.11; chr13:19633659-19673441 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality prior to E11.5. Mice homozygous for a null allele activated in neurons exhibit increased brain size, altered brain architecture, and behavioral changes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079184 Ensembl Gene Model | MGI Sequence Detail 29183 C57BL/6J ±  kb
    transcript ENSMUST00000116468 Ensembl | MGI Sequence Detail 2939 Not Applicable  
    polypeptide ENSMUSP00000112170 Ensembl | MGI Sequence Detail 858 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 17

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1925617, MGI:2145753
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:344335 Zhang H, et al., MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells. Cells. 2023 Aug 8;12(16)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory