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Nxnl2 Gene Detail
Summary
  • Symbol
    Nxnl2
  • Name
    nucleoredoxin-like 2
  • Synonyms
    4930519N16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922374
    NCBI Gene: 75124
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51325058-51329224 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 26.08 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922374
 protein coding gene Chr13:51324256-51329227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020548
 protein coding gene Chr13:50349952-50354435 (+)
A/J MGP_AJ_G0020502
 protein coding gene Chr13:48585048-48589210 (+)
AKR/J MGP_AKRJ_G0020480
 protein coding gene Chr13:49969594-49973748 (+)
BALB/cJ MGP_BALBcJ_G0020498
 protein coding gene Chr13:48780102-48784272 (+)
C3H/HeJ MGP_C3HHeJ_G0020298
 protein coding gene Chr13:49795298-49800489 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020932
 protein coding gene Chr13:51916322-51920484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018514
 protein coding gene Chr13:46384390-46388602 (+)
CAST/EiJ MGP_CASTEiJ_G0019811
 protein coding gene Chr13:49747433-49752995 (+)
CBA/J MGP_CBAJ_G0020257
 protein coding gene Chr13:53943856-53948022 (+)
DBA/2J MGP_DBA2J_G0020380
 protein coding gene Chr13:48144722-48148884 (+)
FVB/NJ MGP_FVBNJ_G0020359
 protein coding gene Chr13:47575596-47579758 (+)
LP/J MGP_LPJ_G0020456
 protein coding gene Chr13:50627830-50631992 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020388
 protein coding gene Chr13:53545148-53549310 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020975
 protein coding gene Chr13:49523412-49527574 (+)
PWK/PhJ MGP_PWKPhJ_G0019568
 protein coding gene Chr13:48073086-48077259 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019395
 protein coding gene Chr13:48422859-48426939 (+)
WSB/EiJ MGP_WSBEiJ_G0019873
 protein coding gene Chr13:49828985-49833135 (+)



Homology
more
  • Human Ortholog
    NXNL2, nucleoredoxin like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXNL2, nucleoredoxin like 2
  • Synonyms
    C9orf121, RDCVF2, RdCVF2L
  • Links
    NCBI Gene ID: 158046
    neXtProt AC: NX_Q5VZ03
    UniProt: Q5VZ03

  • Chr Location
    9q22.1; chr9:88534033-88584510 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit impaired cone and rod electrophysiology, reduced cone density, short photoreceptor outer segment, impaired olfaction and reduced survival of olfactory neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021396 Ensembl Gene Model | MGI Sequence Detail 4167 C57BL/6J ±  kb
    transcript ENSMUST00000021828 Ensembl | MGI Sequence Detail 1167 Not Applicable  
    polypeptide ENSMUSP00000021828 Ensembl | MGI Sequence Detail 156 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 26
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory