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Pmis2 Gene Detail
Summary
  • Symbol
    Pmis2
  • Name
    PMIS2 transmembrane protein
  • Synonyms
    1700071L20Rik, 4930479M11Rik
Location &
Maps
more
  • Sequence Map
    Chr7:30370147-30371030 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922177
 protein coding gene Chr7:30370147-30371030 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032038
 protein coding gene Chr7:29688226-29689108 (-)
A/J MGP_AJ_G0032015
 protein coding gene Chr7:28878060-28878938 (-)
AKR/J MGP_AKRJ_G0031948
 protein coding gene Chr7:29613970-29614850 (-)
BALB/cJ MGP_BALBcJ_G0032022
 protein coding gene Chr7:29066851-29067729 (-)
C3H/HeJ MGP_C3HHeJ_G0031741
 protein coding gene Chr7:30072264-30073147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032488
 protein coding gene Chr7:30646533-30647416 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029538
 protein coding gene Chr7:29905585-29906448 (-)
CAST/EiJ MGP_CASTEiJ_G0031075
 protein coding gene Chr7:23328284-23329166 (-)
CBA/J MGP_CBAJ_G0031707
 protein coding gene Chr7:32101661-32102544 (-)
DBA/2J MGP_DBA2J_G0031859
 protein coding gene Chr7:28607047-28607930 (-)
FVB/NJ MGP_FVBNJ_G0031816
 protein coding gene Chr7:28736135-28737018 (-)
LP/J MGP_LPJ_G0031940
 protein coding gene Chr7:29994662-29995543 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031852
 protein coding gene Chr7:31344528-31345406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032516
 protein coding gene Chr7:29122123-29123004 (-)
PWK/PhJ MGP_PWKPhJ_G0030799
 protein coding gene Chr7:23646988-23647869 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030634
 protein coding gene Chr7:20133391-20134326 (-)
WSB/EiJ MGP_WSBEiJ_G0031185
 protein coding gene Chr7:29510246-29511129 (-)



Homology
more
  • Human Ortholog
    PMIS2, PMIS2 transmembrane protein
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PMIS2, PMIS2 transmembrane protein
  • Synonyms
    IFITMD9
  • Links
    NCBI Gene ID: 111216276
    UniProt: A0A1W2PS18

  • Chr Location
    19q13.12; chr19:35586161-35587296 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal sperm physiology and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      31
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74927 NCBI Gene Model | MGI Sequence Detail 884 C57BL/6J ±  kb
    transcript NR_027848 RefSeq | MGI Sequence Detail 720 C57BL/6  
    polypeptide Q8CES1 UniProt | EBI | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007593 CD225/Dispanin family
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1920744
    References
    more
    • Summaries
      All 20
      Gene Ontology 2
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:185714 Yamaguchi R, et al., Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Mol Biol Cell. 2012 Jul;23(14):2671-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory