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Tbc1d10c Gene Detail
Summary
  • Symbol
    Tbc1d10c
  • Name
    TBC1 domain family, member 10c
  • Synonyms
    1810062O14Rik, Carabin
Location &
Maps
more
  • Sequence Map
    Chr19:4234356-4241194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922072
 protein coding gene Chr19:4233410-4241283 (-)
129S1/SvImJ ENSMUSG00200050945
 protein coding gene Chr19:993932-1001805 (-)
A/J ENSMUSG00195051863
 protein coding gene Chr19:1385168-1393048 (-)
AKR/J ENSMUSG00220043448
 protein coding gene Chr19:1158110-1165983 (-)
BALB/cJ ENSMUSG00180045898
 protein coding gene Chr19:1759921-1767794 (-)
C3H/HeJ ENSMUSG00175009653
 protein coding gene Chr19:1004647-1012525 (-)
C57BL/6NJ ENSMUSG00215043164
 protein coding gene Chr19:1232239-1240112 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022497
 protein coding gene Chr19:929258-936069 (-)
CAST/EiJ ENSTCUG00005027561
 protein coding gene Chr19:1139109-1147012 (-)
CBA/J ENSMUSG00210033316
 protein coding gene Chr19:1004975-1012827 (-)
DBA/2J ENSMUSG00185040988
 protein coding gene Chr19:1381285-1389137 (-)
FVB/NJ ENSMUSG00205050317
 protein coding gene Chr19:1382388-1390258 (-)
JF1/MsJ ENSUMUG00000052172
 protein coding gene Chr19:1366605-1374510 (-)
LP/J ENSMUSG00230051993
 protein coding gene Chr19:2300096-2307969 (-)
NOD/ShiLtJ ENSMUSG00190030081
 protein coding gene Chr19:926255-934128 (-)
NZO/HlLtJ ENSMUSG00225025711
 protein coding gene Chr19:6008945-6016818 (-)
PWK/PhJ ENSLUMG00010005561
 protein coding gene Chr19:1143332-1151243 (-)
SPRET/EiJ ENSMSPG00010039599
 protein coding gene Chr19:1124439-1131365 (-)
WSB/EiJ ENSIUOG00005045975
 protein coding gene Chr19:1010323-1018192 (-)



Homology
more
  • Human Ortholog
    TBC1D10C, TBC1 domain family member 10C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D10C, TBC1 domain family member 10C
  • Synonyms
    CARABIN, EPI64C
  • Links
    NCBI Gene ID: 374403
    UniProt: Q8IV04

  • Chr Location
    11q13.2; chr11:67398454-67410092 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spontaneous T cell activation and increased B cell response to ovalbumin, NP-LPS and Borrelia burgdorferi infection, and increased autoimmune response to CpG-DNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    1
  • cDNA Data
    26
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108995 NCBI Gene Model | MGI Sequence Detail 6839 C57BL/6J ±  kb
    transcript NM_178650 RefSeq | MGI Sequence Detail 1781 C57BL/6  
    polypeptide Q8C9V1 UniProt | EBI | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147528
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:321948 Ni X, et al., Carabin Deficiency Aggravates Hepatic Ischemia-Reperfusion Injury Through Promoting Neutrophil Trafficking via Ras and Calcineurin Signaling. Front Immunol. 2022;13:773291
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory