About   Help   FAQ
Mdga1 Gene Detail
Summary
  • Symbol
    Mdga1
  • Name
    MAM domain containing glycosylphosphatidylinositol anchor 1
  • Synonyms
    1200011I03Rik, Mamdc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922012
    NCBI Gene: 74762
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:30046930-30107557 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.54 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1712 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922012
 protein coding gene Chr17:30046923-30189061 (-)
129S1/SvImJ ENSMUSG00200045976
 protein coding gene Chr17:25702336-25843772 (-)
A/J ENSMUSG00195054352
 protein coding gene Chr17:26529310-26671036 (-)
AKR/J ENSMUSG00220050581
 protein coding gene Chr17:25571405-25713133 (-)
BALB/cJ ENSMUSG00180046463
 protein coding gene Chr17:26004913-26146357 (-)
C3H/HeJ ENSMUSG00175048315
 protein coding gene Chr17:25559608-25701326 (-)
C57BL/6NJ ENSMUSG00215049795
 protein coding gene Chr17:25563099-25705033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021352
 protein coding gene Chr17:25704171-25766397 (-)
CAST/EiJ ENSTCUG00005047423
 protein coding gene Chr17:26294488-26436101 (-)
CBA/J ENSMUSG00210050615
 protein coding gene Chr17:25398044-25539751 (-)
DBA/2J ENSMUSG00185039982
 protein coding gene Chr17:27608494-27749931 (-)
FVB/NJ ENSMUSG00205051499
 protein coding gene Chr17:25876480-26018408 (-)
JF1/MsJ ENSUMUG00000026111
 protein coding gene Chr17:27083553-27231187 (-)
LP/J ENSMUSG00230054961
 protein coding gene Chr17:29128053-29269478 (-)
NOD/ShiLtJ ENSMUSG00190052669
 protein coding gene Chr17:25514092-25655876 (-)
NZO/HlLtJ ENSMUSG00225051566
 protein coding gene Chr17:31106938-31248657 (-)
PWK/PhJ ENSLUMG00010041977
 protein coding gene Chr17:24992588-25138721 (-)
SPRET/EiJ ENSMSPG00010049480
 protein coding gene Chr17:26279365-26421254 (-)
WSB/EiJ ENSIUOG00005049598
 protein coding gene Chr17:26281915-26423688 (-)



Homology
more
  • Human Ortholog
    MDGA1, MAM domain containing glycosylphosphatidylinositol anchor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDGA1, MAM domain containing glycosylphosphatidylinositol anchor 1
  • Synonyms
    GPIM, MAMDC3
  • Links
    NCBI Gene ID: 266727
    UniProt: Q8NFP4

  • Chr Location
    6p21.2; chr6:37630679-37699306 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuronal migration during corticogenesis that is resolved by P7
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    51
  • cDNA Data
    44
  • Literature Summary
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74762 NCBI Gene Model | MGI Sequence Detail 60628 C57BL/6J ±  kb
transcript NM_001368423 RefSeq | MGI Sequence Detail 8288 C57BL/6  
polypeptide Q0PMG2 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010261 MAM domain-containing glycosylphosphatidylinositol anchor protein 1
    (term hierarchy)
  • InterPro Domains
    IPR050958 Cell Adhesion and Cytoskeletal Organization
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR003599 Immunoglobulin domain subtype
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003598 Immunoglobulin subtype 2
    IPR000998 MAM domain
    IPR051560 MAM domain-containing protein
  • GlyGen
    Q0PMG2 11 sites, 11 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 45
    cDNA 44
    Other 1
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 56
    Developmental Gene Expression 15
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:368618 Wang X, et al., Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula. Theranostics. 2025;15(5):1842-1863
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory