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Mroh2b Gene Detail
Summary
  • Symbol
    Mroh2b
  • Name
    maestro heat-like repeat family member 2B
  • Synonyms
    4930455B06Rik, Heatr7b2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921905
    NCBI Gene: 223825
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:4928219-4991687 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.98 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1808 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921905
 protein coding gene Chr15:4927697-4991689 (+)
129S1/SvImJ ENSMUSG00200030154
 protein coding gene Chr15:1902735-1967531 (+)
A/J ENSMUSG00195009995
 protein coding gene Chr15:1819822-1884643 (+)
AKR/J ENSMUSG00220022264
 protein coding gene Chr15:1702365-1767233 (+)
BALB/cJ ENSMUSG00180033692
 protein coding gene Chr15:1797288-1862098 (+)
C3H/HeJ ENSMUSG00175030003
 protein coding gene Chr15:1951959-2016792 (+)
C57BL/6NJ ENSMUSG00215022548
 protein coding gene Chr15:1809223-1874044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019632
 protein coding gene Chr15:1561004-1624489 (+)
CAST/EiJ ENSTCUG00005023749
 protein coding gene Chr15:1884519-1952995 (+)
CBA/J ENSMUSG00210024977
 protein coding gene Chr15:1936915-2001761 (+)
DBA/2J ENSMUSG00185029632
 protein coding gene Chr15:1895531-1960340 (+)
FVB/NJ ENSMUSG00205016900
 protein coding gene Chr15:1810841-1875750 (+)
JF1/MsJ ENSUMUG00000025775
 protein coding gene Chr15:1947353-2013522 (+)
LP/J ENSMUSG00230017242
 protein coding gene Chr15:5396062-5460854 (+)
NOD/ShiLtJ ENSMUSG00190009598
 protein coding gene Chr15:1875712-1940635 (+)
NZO/HlLtJ ENSMUSG00225034023
 protein coding gene Chr15:5641322-5706131 (+)
PWK/PhJ ENSLUMG00010032474
 protein coding gene Chr15:1984564-2050845 (+)
SPRET/EiJ ENSMSPG00010029863
 protein coding gene Chr15:1967026-2032337 (+)
WSB/EiJ ENSIUOG00005027912
 protein coding gene Chr15:1801203-1866071 (+)



Homology
more
  • Human Ortholog
    MROH2B, maestro heat like repeat family member 2B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MROH2B, maestro heat like repeat family member 2B
  • Synonyms
    HEATR7B2, SPIF
  • Links
    NCBI Gene ID: 133558
    UniProt: Q7Z745

  • Chr Location
    5p13.1; chr5:40998017-41071342 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knock-out mice exhibit embryonic lethality before 10 dpc. Higher than the expected ratio of heterozygous to wild-type mice are seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022155 Ensembl Gene Model | MGI Sequence Detail 63469 C57BL/6J ±  kb
transcript ENSMUST00000045736 Ensembl | MGI Sequence Detail 4829 Not Applicable  
polypeptide ENSMUSP00000036148 Ensembl | MGI Sequence Detail 1581 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031444 maestro heat-like repeat-containing protein family member 2B
    (term hierarchy)
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR045206 Maestro heat-like repeat-containing protein
    IPR048465 Maestro-like, HEAT-repeats domain
    IPR055406 Maestro/Maestro-like, HEAT-repeats domain
    IPR055408 MROH2B-like, HEAT-repeats domain
    IPR056282 MROH2B-like, N-terminal HEAT-repeats domain
  • GlyGen
    Q7M6Y6 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory