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Sbf2 Gene Detail
Summary
  • Symbol
    Sbf2
  • Name
    SET binding factor 2
  • Synonyms
    4833411B01Rik, B430219L04Rik, mMTMH1, Mtmr13, SBF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921831
    NCBI Gene: 319934
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109907220-110214129 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.70 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7286 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921831
 protein coding gene Chr7:109907218-110215150 (-)
129S1/SvImJ ENSMUSG00200032579
 protein coding gene Chr7:96449853-96757093 (-)
A/J ENSMUSG00195054625
 protein coding gene Chr7:100945750-101252986 (-)
AKR/J ENSMUSG00220037241
 protein coding gene Chr7:94349252-94656496 (-)
BALB/cJ ENSMUSG00180035598
 protein coding gene Chr7:97621386-97928623 (-)
C3H/HeJ ENSMUSG00175045457
 protein coding gene Chr7:98257297-98564528 (-)
C57BL/6NJ ENSMUSG00215049623
 protein coding gene Chr7:97562105-97869322 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030323
 protein coding gene Chr7:112538208-112894072 (-)
CAST/EiJ ENSTCUG00005037335
 protein coding gene Chr7:100935683-101253832 (-)
CBA/J ENSMUSG00210038482
 protein coding gene Chr7:98084367-98391587 (-)
DBA/2J ENSMUSG00185020920
 protein coding gene Chr7:102434649-102741718 (-)
FVB/NJ ENSMUSG00205037739
 protein coding gene Chr7:98046708-98353945 (-)
JF1/MsJ ENSUMUG00000022340
 protein coding gene Chr7:107450639-107762667 (-)
LP/J ENSMUSG00230047062
 protein coding gene Chr7:108535633-108842846 (-)
NOD/ShiLtJ ENSMUSG00190042705
 protein coding gene Chr7:98241474-98554752 (-)
NZO/HlLtJ ENSMUSG00225015578
 protein coding gene Chr7:106753718-107061010 (-)
PWK/PhJ ENSLUMG00010039272
 protein coding gene Chr7:96575278-96892398 (-)
SPRET/EiJ ENSMSPG00010039172
 protein coding gene Chr7:97719386-98048744 (-)
WSB/EiJ ENSIUOG00005045754
 protein coding gene Chr7:98884286-99203178 (-)



Homology
more
  • Human Ortholog
    SBF2, SET binding factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SBF2, SET binding factor 2
  • Synonyms
    CMT4B2, DENND7B, MTMR13
  • Links
    NCBI Gene ID: 81846
    UniProt: Q86WG5

  • Chr Location
    11p15.4; chr11:9776776-10304877 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sbf2 mouse models; 1 with human SBF2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    5 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles display progressive misfolding of myelin sheaths and abnormal nerve electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    50
  • cDNA Data
    125
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038371 Ensembl Gene Model | MGI Sequence Detail 306910 C57BL/6J ±  kb
transcript ENSMUST00000033058 Ensembl | MGI Sequence Detail 7154 Not Applicable  
polypeptide ENSMUSP00000033058 Ensembl | MGI Sequence Detail 1872 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    cDNA 125
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2141827, MGI:2141904, MGI:2443006
References
more
  • Summaries
    All 57
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:369747 Lin S, et al., Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice. Dev Cell. 2025 Jun 24;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory