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Kcmf1 Gene Detail
Summary
  • Symbol
    Kcmf1
  • Name
    potassium channel modulatory factor 1
  • Synonyms
    1700094M07Rik, clone DEBT-91, Pmcf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921537
    NCBI Gene: 74287
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72818097-72876962 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.30 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921537
 protein coding gene Chr6:72818097-72876962 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030884
 protein coding gene Chr6:73438391-73501357 (-)
A/J MGP_AJ_G0030854
 protein coding gene Chr6:70576186-70635163 (-)
AKR/J MGP_AKRJ_G0030783
 protein coding gene Chr6:72670797-72728801 (-)
BALB/cJ MGP_BALBcJ_G0030865
 protein coding gene Chr6:70601794-70659241 (-)
C3H/HeJ MGP_C3HHeJ_G0030847
 protein coding gene Chr6:111527502-111590017 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031323
 protein coding gene Chr6:75350400-75418384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028512
 protein coding gene Chr6:69712668-69769826 (-)
CAST/EiJ MGP_CASTEiJ_G0029973
 protein coding gene Chr6:72529462-72591333 (-)
CBA/J MGP_CBAJ_G0030552
 protein coding gene Chr6:78434249-78504506 (-)
DBA/2J MGP_DBA2J_G0030704
 protein coding gene Chr6:69962373-70019083 (-)
FVB/NJ MGP_FVBNJ_G0030657
 protein coding gene Chr6:69357606-69415175 (-)
LP/J MGP_LPJ_G0030783
 protein coding gene Chr6:73340377-73406224 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030692
 protein coding gene Chr6:81795568-81861965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031349
 protein coding gene Chr6:72487688-72550031 (-)
PWK/PhJ MGP_PWKPhJ_G0029689
 protein coding gene Chr6:68888208-68948924 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029517
 protein coding gene Chr6:71229074-71291626 (-)
WSB/EiJ MGP_WSBEiJ_G0030055
 protein coding gene Chr6:72859055-72922120 (-)



Homology
more
  • Human Ortholog
    KCMF1, potassium channel modulatory factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCMF1, potassium channel modulatory factor 1
  • Synonyms
    DEBT91, FIGC, PCMF, ZZZ1
  • Links
    NCBI Gene ID: 56888
    neXtProt AC: NX_Q9P0J7
    UniProt: Q9P0J7

  • Chr Location
    2p11.2; chr2:84971093-85059472 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit some perinatal and postnatal lethality but mice that survive to adulthood exhibit normal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    21
  • cDNA Data
    106
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74287 NCBI Gene Model | MGI Sequence Detail 58866 C57BL/6J ±  kb
transcript NM_019715 RefSeq | MGI Sequence Detail 3251 ZRU/MplStud  
polypeptide Q80UY2 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    cDNA 107
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory