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Dmgdh Gene Detail
Summary
  • Symbol
    Dmgdh
  • Name
    dimethylglycine dehydrogenase precursor
  • Synonyms
    1200014D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921379
    NCBI Gene: 74129
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:93810944-93889331 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2907 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921379
 protein coding gene Chr13:93810941-93889341 (+)
129S1/SvImJ ENSMUSG00200008282
 protein coding gene Chr13:88309295-88388210 (+)
A/J ENSMUSG00195023700
 protein coding gene Chr13:88808145-88884471 (+)
AKR/J ENSMUSG00220013120
 protein coding gene Chr13:87290077-87369027 (+)
BALB/cJ ENSMUSG00180015813
 protein coding gene Chr13:89345652-89424609 (+)
C3H/HeJ ENSMUSG00175022411
 protein coding gene Chr13:89509563-89588474 (+)
C57BL/6NJ ENSMUSG00215002896
 protein coding gene Chr13:89409238-89487703 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018782
 protein coding gene Chr13:87356761-87435630 (+)
CAST/EiJ ENSTCUG00005008952
 protein coding gene Chr13:88604746-88682731 (+)
CBA/J ENSMUSG00210024042
 protein coding gene Chr13:88831248-88910152 (+)
DBA/2J ENSMUSG00185016576
 protein coding gene Chr13:92491971-92570895 (+)
FVB/NJ ENSMUSG00205008100
 protein coding gene Chr13:88301533-88380459 (+)
JF1/MsJ ENSUMUG00000020927
 protein coding gene Chr13:92176156-92254287 (+)
LP/J ENSMUSG00230033288
 protein coding gene Chr13:102509977-102588913 (+)
NOD/ShiLtJ ENSMUSG00190018401
 protein coding gene Chr13:89191676-89270118 (+)
NZO/HlLtJ ENSMUSG00225033446
 protein coding gene Chr13:95023651-95102563 (+)
PWK/PhJ ENSLUMG00010011281
 protein coding gene Chr13:88280288-88364522 (+)
SPRET/EiJ ENSMSPG00010006621
 protein coding gene Chr13:89536621-89616038 (+)
WSB/EiJ ENSIUOG00005030668
 protein coding gene Chr13:88215092-88292937 (+)



Homology
more
  • Human Ortholog
    DMGDH, dimethylglycine dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMGDH, dimethylglycine dehydrogenase
  • Synonyms
    DMGDHD, ME2GLYDH
  • Links
    NCBI Gene ID: 29958
    UniProt: Q9UI17

  • Chr Location
    5q14.1; chr5:78996974-79236038 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DMGDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    123
  • cDNA Data
    27
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74129 NCBI Gene Model | MGI Sequence Detail 78388 C57BL/6J ±  kb
    transcript NM_028772 RefSeq | MGI Sequence Detail 2979 C57BL/6  
    polypeptide Q9DBT9 UniProt | EBI | MGI Sequence Detail 869 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145286
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory