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Lima1 Gene Detail
Summary
  • Symbol
    Lima1
  • Name
    LIM domain and actin binding 1
  • Synonyms
    1110021C24Rik, 3526402A12Rik, epithelial protein lost in neoplasm, EPLIN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920992
    NCBI Gene: 65970
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99676351-99773292 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2946 from dbSNP Build 142
  • Strain Annotations
    23
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920992
 protein coding gene Chr15:99676351-99773337 (-)
129S1/SvImJ ENSMUSG00200048971
 protein coding gene Chr15:96879954-96921893 (-)
A/J ENSMUSGG00195054959
 protein coding gene Chr15:96787549-96810905 (-)
A/J ENSMUSG00195036252
 protein coding gene Chr15:96745709-96787897 (-)
AKR/J ENSMUSGG00220054349
 protein coding gene Chr15:96794211-96818244 (-)
AKR/J ENSMUSG00220042782
 protein coding gene Chr15:96752898-96794559 (-)
BALB/cJ ENSMUSG00180035567
 protein coding gene Chr15:96655563-96697300 (-)
BALB/cJ ENSMUSGG00180055043
 protein coding gene Chr15:96696952-96720696 (-)
C3H/HeJ ENSMUSGG00175054622
 protein coding gene Chr15:96967520-96990864 (-)
C3H/HeJ ENSMUSG00175040117
 protein coding gene Chr15:96925692-96967868 (-)
C57BL/6NJ ENSMUSGG00215055238
 protein coding gene Chr15:96756087-96780118 (-)
C57BL/6NJ ENSMUSG00215049839
 protein coding gene Chr15:96714778-96756435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020279
 protein coding gene Chr15:93488157-93578485 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055026
 protein coding gene Chr15:96753867-96777614 (-)
CBA/J ENSMUSG00210026346
 protein coding gene Chr15:96712483-96754215 (-)
DBA/2J ENSMUSG00185035259
 protein coding gene Chr15:96759288-96800943 (-)
DBA/2J ENSMUSGG00185057381
 protein coding gene Chr15:96800595-96824623 (-)
FVB/NJ ENSMUSGG00205054061
 protein coding gene Chr15:96505068-96529100 (-)
FVB/NJ ENSMUSG00205024295
 protein coding gene Chr15:96463761-96505416 (-)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSGG00190054990
 protein coding gene Chr15:96770562-96794576 (-)
NOD/ShiLtJ ENSMUSG00190045327
 protein coding gene Chr15:96729267-96770910 (-)
NZO/HlLtJ ENSMUSG00225042550
 protein coding gene Chr15:100351635-100393290 (-)
NZO/HlLtJ ENSMUSGG00225055321
 protein coding gene Chr15:100392942-100416969 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LIMA1, LIM domain and actin binding 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIMA1, LIM domain and actin binding 1
  • Synonyms
    EPLIN, LDLCQ8, SREBP3
  • Links
    NCBI Gene ID: 51474
    UniProt: Q9UHB6

  • Chr Location
    12q13.12; chr12:50175788-50283524 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased intestinal cholesterol absorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    39
  • cDNA Data
    19
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65970 NCBI Gene Model | MGI Sequence Detail 96942 C57BL/6J ±  kb
    transcript NR_177985 RefSeq | MGI Sequence Detail 4257 ZRU/MplStud  
    polypeptide Q9ERG0 UniProt | EBI | MGI Sequence Detail 753 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009814 LIM domain and actin-binding protein 1
      (term hierarchy)
    • InterPro Domains
      IPR028740 LIM domain and actin-binding protein 1, Lim domain
      IPR001781 Zinc finger, LIM-type
    • GlyGen
      Q9ERG0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3
      Antibodies 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1196235, MGI:2443059
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 40
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory