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Psma8 Gene Detail
Summary
  • Symbol
    Psma8
  • Name
    proteasome subunit alpha 8
  • Synonyms
    2410072D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920927
    NCBI Gene: 73677
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:14839208-14895358 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 8.25 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1134 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920927
 protein coding gene Chr18:14839192-14895358 (+)
129S1/SvImJ ENSMUSG00200019572
 protein coding gene Chr18:11811680-11861531 (+)
A/J ENSMUSG00195002088
 protein coding gene Chr18:11975266-12025119 (+)
AKR/J ENSMUSG00220011239
 protein coding gene Chr18:11969741-12019596 (+)
BALB/cJ ENSMUSG00180003743
 protein coding gene Chr18:12434745-12484617 (+)
C3H/HeJ ENSMUSG00175004344
 protein coding gene Chr18:11973868-12023746 (+)
C57BL/6NJ ENSMUSG00215003411
 protein coding gene Chr18:11680379-11736535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022015
 protein coding gene Chr18:11254993-11304653 (+)
CAST/EiJ ENSTCUG00005014292
 protein coding gene Chr18:11810920-11865192 (+)
CBA/J ENSMUSG00210020282
 protein coding gene Chr18:11982695-12032569 (+)
DBA/2J ENSMUSG00185007373
 protein coding gene Chr18:11980416-12036568 (+)
FVB/NJ ENSMUSG00205016006
 protein coding gene Chr18:11739989-11796721 (+)
JF1/MsJ ENSUMUG00000016618
 protein coding gene Chr18:12086254-12136117 (+)
LP/J ENSMUSG00230011958
 protein coding gene Chr18:14038605-14088452 (+)
NOD/ShiLtJ ENSMUSG00190016603
 protein coding gene Chr18:11750892-11800767 (+)
NZO/HlLtJ ENSMUSG00225027675
 protein coding gene Chr18:13961983-14018134 (+)
PWK/PhJ ENSLUMG00010015239
 protein coding gene Chr18:12314072-12363941 (+)
SPRET/EiJ ENSMSPG00010004631
 protein coding gene Chr18:11953830-12000404 (+)
WSB/EiJ ENSIUOG00005018827
 protein coding gene Chr18:11875514-11925375 (+)



Homology
more
  • Human Ortholog
    PSMA8, proteasome 20S subunit alpha 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMA8, proteasome 20S subunit alpha 8
  • Synonyms
    PSMA7L
  • Links
    NCBI Gene ID: 143471
    UniProt: Q8TAA3

  • Chr Location
    18q11.2; chr18:26133852-26193355 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation are infertile with arrest of meiosis at M phase; however, females are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036743 Ensembl Gene Model | MGI Sequence Detail 56151 C57BL/6J ±  kb
    transcript ENSMUST00000040860 Ensembl | MGI Sequence Detail 1692 Not Applicable  
    polypeptide ENSMUSP00000042590 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory