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Pdxdc1 Gene Detail
Summary
  • Symbol
    Pdxdc1
  • Name
    pyridoxal-dependent decarboxylase domain containing 1
  • Synonyms
    2210010A19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920909
    NCBI Gene: 94184
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13651012-13720995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920909
 protein coding gene Chr16:13651012-13721018 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022537
 protein coding gene Chr16:10836103-10926350 (-)
A/J MGP_AJ_G0022499
 protein coding gene Chr16:10241412-10314186 (-)
AKR/J MGP_AKRJ_G0022475
 protein coding gene Chr16:10686745-10763117 (-)
BALB/cJ MGP_BALBcJ_G0022503
 protein coding gene Chr16:10408043-10480630 (-)
C3H/HeJ MGP_C3HHeJ_G0022270
 protein coding gene Chr16:10779622-10855562 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022952
 protein coding gene Chr16:10996639-11077531 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020472
 protein coding gene Chr16:10330848-10401772 (-)
CAST/EiJ MGP_CASTEiJ_G0021797
 protein coding gene Chr16:10798398-10872805 (-)
CBA/J MGP_CBAJ_G0022239
 protein coding gene Chr16:11533069-11613303 (-)
DBA/2J MGP_DBA2J_G0022370
 protein coding gene Chr16:10230304-10303914 (-)
FVB/NJ MGP_FVBNJ_G0022346
 protein coding gene Chr16:10217089-10287411 (-)
LP/J MGP_LPJ_G0022438
 protein coding gene Chr16:10741010-10820352 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022368
 protein coding gene Chr16:11153901-11230937 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022965
 protein coding gene Chr16:10662316-10736261 (-)
PWK/PhJ MGP_PWKPhJ_G0021539
 protein coding gene Chr16:10496091-10568607 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021367
 protein coding gene Chr16:10651635-10725952 (-)
WSB/EiJ MGP_WSBEiJ_G0021845
 protein coding gene Chr16:10680490-10759159 (-)



Homology
more
  • Human Ortholog
    PDXDC1, pyridoxal dependent decarboxylase domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDXDC1, pyridoxal dependent decarboxylase domain containing 1
  • Synonyms
    LP8165
  • Links
    NCBI Gene ID: 23042
    neXtProt AC: NX_Q6P996
    UniProt: Q6P996

  • Chr Location
    16p13.11; chr16:14974591-15153218 (+)  GRCh38
  • Human Ortholog
    PDXDC2P, pyridoxal dependent decarboxylase domain containing 2, pseudogene
  • Synonyms
    PDXDC2
  • Links
    NCBI Gene ID: 109731405

  • Chr Location
    chr16:70010751-70065948 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    31
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022680 Ensembl Gene Model | MGI Sequence Detail 69984 C57BL/6J ±  kb
    transcript ENSMUST00000023361 Ensembl | MGI Sequence Detail 4228 Not Applicable  
    polypeptide ENSMUSP00000023361 Ensembl | MGI Sequence Detail 789 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000032500 pyridoxal-dependent decarboxylase domain-containing protein 1
      (term hierarchy)
    • EC
      4.1.1.-
    • InterPro Domains
      IPR002129 Pyridoxal phosphate-dependent decarboxylase
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146345
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333344 Song YQ, et al., Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight. J Mol Med (Berl). 2022 May;100(5):723-734
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory