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Ccrl2 Gene Detail
Summary
  • Symbol
    Ccrl2
  • Name
    C-C motif chemokine receptor-like 2
  • Synonyms
    1810047I05Rik, Ackr5, CCR11, Cmkbr1l2, L-CCR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920904
    NCBI Gene: 54199
  • Alliance
    genome feature page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110883902-110886586 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 60.92 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920904
 protein coding gene Chr9:110883554-110886587 (-)
129S1/SvImJ ENSMUSG00200038288
 protein coding gene Chr9:107970383-107973413 (-)
A/J ENSMUSG00195033884
 protein coding gene Chr9:107264163-107267193 (-)
AKR/J ENSMUSG00220022310
 protein coding gene Chr9:107599592-107602622 (-)
BALB/cJ ENSMUSG00180027619
 protein coding gene Chr9:107718840-107721870 (-)
C3H/HeJ ENSMUSG00175037122
 protein coding gene Chr9:107934637-107937667 (-)
C57BL/6NJ ENSMUSG00215021246
 protein coding gene Chr9:107821288-107824321 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032753
 protein coding gene Chr9:106334539-106337607 (-)
CAST/EiJ ENSTCUG00005024673
 protein coding gene Chr9:107628178-107631210 (-)
CBA/J ENSMUSG00210028094
 protein coding gene Chr9:107656834-107659864 (-)
DBA/2J ENSMUSG00185033006
 protein coding gene Chr9:107982554-107985584 (-)
FVB/NJ ENSMUSG00205048670
 protein coding gene Chr9:107930658-107933688 (-)
JF1/MsJ ENSUMUG00000032677
 protein coding gene Chr9:107757794-107760824 (-)
LP/J ENSMUSG00230049698
 protein coding gene Chr9:108102480-108105510 (-)
NOD/ShiLtJ ENSMUSG00190044448
 protein coding gene Chr9:107570234-107573264 (-)
NZO/HlLtJ ENSMUSG00225024316
 protein coding gene Chr9:108360917-108363950 (-)
PWK/PhJ ENSLUMG00010038516
 protein coding gene Chr9:107764351-107767383 (-)
SPRET/EiJ ENSMSPG00010045188
 protein coding gene Chr9:109556822-109559605 (-)
WSB/EiJ ENSIUOG00005041776
 protein coding gene Chr9:107024420-107027453 (-)



Homology
more
  • Human Ortholog
    CCRL2, C-C motif chemokine receptor like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCRL2, C-C motif chemokine receptor like 2
  • Synonyms
    ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
  • Links
    NCBI Gene ID: 9034
    UniProt: O00421

  • Chr Location
    3p21.31; chr3:46407144-46412997 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    75
  • cDNA Data
    23
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54199 NCBI Gene Model | MGI Sequence Detail 2685 C57BL/6J ±  kb
    transcript NM_017466 RefSeq | MGI Sequence Detail 2121 ZRU/MplStud  
    polypeptide O35457 UniProt | EBI | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
    • Latest
      J:378612 Li G, et al., Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2(+) macrophages. Immunity. 2025 Jul 8;58(7):1847-1861.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory