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Nwd2 Gene Detail
Summary
  • Symbol
    Nwd2
  • Name
    NACHT and WD repeat domain containing 2
  • Synonyms
    3110047P20Rik, B830017A01Rik, mKIAA1239
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920464
    NCBI Gene: 319807
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:63806446-63967889 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 32.80 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    631 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920464
 protein coding gene Chr5:63806445-63967889 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029562
 protein coding gene Chr5:63208714-63382227 (+)
A/J MGP_AJ_G0029530
 protein coding gene Chr5:60850548-61017981 (+)
AKR/J MGP_AKRJ_G0029478
 protein coding gene Chr5:62741219-62917439 (+)
BALB/cJ MGP_BALBcJ_G0029539
 protein coding gene Chr5:61528850-61696266 (+)
C3H/HeJ MGP_C3HHeJ_G0029262
 protein coding gene Chr5:63110829-63291471 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029993
 protein coding gene Chr5:65845760-66004909 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027233
 protein coding gene Chr5:56973697-57132162 (+)
CAST/EiJ MGP_CASTEiJ_G0028670
 protein coding gene Chr5:62185349-62357377 (+)
CBA/J MGP_CBAJ_G0029231
 protein coding gene Chr5:67918554-68103848 (+)
DBA/2J MGP_DBA2J_G0029377
 protein coding gene Chr5:60888591-61044593 (+)
FVB/NJ MGP_FVBNJ_G0029337
 protein coding gene Chr5:60067646-60232546 (+)
LP/J MGP_LPJ_G0029462
 protein coding gene Chr5:63662187-63835852 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029365
 protein coding gene Chr5:70896649-71066172 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030026
 protein coding gene Chr5:62458667-62624140 (+)
PWK/PhJ MGP_PWKPhJ_G0028394
 protein coding gene Chr5:59859523-60028253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028228
 protein coding gene Chr5:61794988-61967722 (+)
WSB/EiJ MGP_WSBEiJ_G0028751
 protein coding gene Chr5:62659614-62826600 (+)



Homology
more
  • Human Ortholog
    NWD2, NACHT and WD repeat domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NWD2, NACHT and WD repeat domain containing 2
  • Synonyms
    KIAA1239
  • Links
    NCBI Gene ID: 57495
    neXtProt AC: NX_Q9ULI1
    UniProt: Q9ULI1

  • Chr Location
    4p14; chr4:37244743-37449463 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    37
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319807 NCBI Gene Model | MGI Sequence Detail 161444 C57BL/6J ±  kb
    transcript NM_177006 RefSeq | MGI Sequence Detail 8539 C57BL/6  
    polypeptide Q6P5U7 UniProt | EBI | MGI Sequence Detail 1742 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000060133 NACHT and WD repeat domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR041664 Orc1-like, AAA ATPase domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442762
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Phenotypes 19
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:331484 Yamada S, et al., Identification and expression profile of novel STAND gene Nwd2 in the mouse central nervous system. Gene Expr Patterns. 2022 Dec;46:119284
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory